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Brendan J. Frey
Researcher at University of Toronto
Publications - 257
Citations - 41927
Brendan J. Frey is an academic researcher from University of Toronto. The author has contributed to research in topics: Graphical model & Cluster analysis. The author has an hindex of 71, co-authored 256 publications receiving 37739 citations. Previous affiliations of Brendan J. Frey include University of Wisconsin–Milwaukee & Microsoft.
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Journal ArticleDOI
Factor graphs and the sum-product algorithm
TL;DR: A generic message-passing algorithm, the sum-product algorithm, that operates in a factor graph, that computes-either exactly or approximately-various marginal functions derived from the global function.
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Clustering by Passing Messages Between Data Points
Brendan J. Frey,Delbert Dueck +1 more
TL;DR: A method called “affinity propagation,” which takes as input measures of similarity between pairs of data points, which found clusters with much lower error than other methods, and it did so in less than one-hundredth the amount of time.
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Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
TL;DR: It is estimated that transcripts from ∼95% of multiexon genes undergoAlternative splicing and that there are ∼100,000 intermediate- to high-abundance alternative splicing events in major human tissues.
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Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
TL;DR: This work shows that sequence specificities can be ascertained from experimental data with 'deep learning' techniques, which offer a scalable, flexible and unified computational approach for pattern discovery.
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A compendium of RNA-binding motifs for decoding gene regulation
Debashish Ray,Hilal Kazan,Kate B. Cook,Matthew T. Weirauch,Matthew T. Weirauch,Hamed S. Najafabadi,Xiao Li,Serge Gueroussov,Mihai Albu,Hong Zheng,Ally Yang,Hong Na,Manuel Irimia,Leah H. Matzat,Ryan K. Dale,Sarah A. Smith,Christopher A. Yarosh,Seth M. Kelly,Behnam Nabet,D. Mecenas,Weimin Li,Rakesh S. Laishram,Mei Qiao,Howard D. Lipshitz,Fabio Piano,Anita H. Corbett,Russ P. Carstens,Brendan J. Frey,Richard A. Anderson,Kristen W. Lynch,Luiz O. F. Penalva,Elissa P. Lei,Andrew G. Fraser,Benjamin J. Blencowe,Quaid Morris,Timothy P. Hughes +35 more
TL;DR: A systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes, provides an unprecedented overview of RNA- binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukARYotes.