B
Brett Johnson
Researcher at Johns Hopkins University
Publications - 2
Citations - 236
Brett Johnson is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ubiquitin ligase & Neurodegeneration. The author has an hindex of 1, co-authored 2 publications receiving 232 citations.
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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
Han Seok Ko,Rainer von Coelln,Sathya R. Sriram,Seong Who Kim,Kenny K.K. Chung,Olga Pletnikova,Juan C. Troncoso,Brett Johnson,Roya Saffary,Eyleen L. K. Goh,Hongjun Song,Bum Joon Park,Min Jung Kim,Min Jung Kim,Sunghoon Kim,Valina L. Dawson,Ted M. Dawson +16 more
TL;DR: This study clearly identifies p38 as an important authentic pathophysiologic substrate of parkin, and shows that adenovirus-mediated overexpression of p38 in the substantia nigra in mice leads to loss of dopaminergic neurons.