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Brian C. Capell
Researcher at University of Pennsylvania
Publications - 61
Citations - 4478
Brian C. Capell is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Biology & Epigenetics. The author has an hindex of 21, co-authored 44 publications receiving 3614 citations. Previous affiliations of Brian C. Capell include New York University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou,Kanad Ghosh,Maria Grazia Vizioli,Jiajun Zhu,Payel Sen,Kirk J. Wangensteen,Johayra Simithy,Yemin Lan,Yanping Lin,Zhuo Zhou,Brian C. Capell,Caiyue Xu,Mingang Xu,Julia E. Kieckhaefer,Tianying Jiang,Michal Shoshkes-Carmel,K M Ahasan Al Tanim,Glen N. Barber,John T. Seykora,Sarah E. Millar,Klaus H. Kaestner,Benjamin A. Garcia,Peter D. Adams,Peter D. Adams,Shelley L. Berger +24 more
TL;DR: It is shown that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING (cyclic GMP–AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.
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Human laminopathies: nuclei gone genetically awry.
TL;DR: The study of LMNA, its products and the phenotypes that result from its mutation have provided important insights into subjects ranging from transcriptional regulation, the cell biology of the nuclear lamina and mechanisms of ageing.
Journal ArticleDOI
Autophagy mediates degradation of nuclear lamina
Zhixun Dou,Caiyue Xu,Greg Donahue,Takeshi Shimi,Ji-An Pan,Jiajun Zhu,Andrejs Ivanov,Brian C. Capell,Adam M. Drake,Parisha P. Shah,Joseph M. Catanzaro,M. Daniel Ricketts,Trond Lamark,Stephen A. Adam,Ronen Marmorstein,Wei-Xing Zong,Terje Johansen,Robert D. Goldman,Peter D. Adams,Shelley L. Berger +19 more
TL;DR: The study suggests that this new function of autophagy acts as a guarding mechanism protecting cells from tumorigenesis, and prevents activated RAS-induced lamin B1 loss and attenuates oncogene-induced senescence in primary human cells.
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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
Parisha P. Shah,Greg Donahue,Gabriel L. Otte,Brian C. Capell,David M. Nelson,Kajia Cao,Varun Aggarwala,Hazel A Cruickshanks,Taranjit Singh Rai,Tony McBryan,Brian D. Gregory,Peter D. Adams,Shelley L. Berger +12 more
TL;DR: Comparing genome-wide Lys4 trimethylation on histone H3 and H3K27me3 distributions between proliferating and senescent human cells found dramatic differences in senescence, suggesting that pre-malignant senescent chromatin changes foreshadow epigenetic cancer changes.
Journal ArticleDOI
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
Brian C. Capell,Michael R. Erdos,James P. Madigan,James J. Fiordalisi,Renee Varga,Karen N. Conneely,Leslie B. Gordon,Channing J. Der,Adrienne D. Cox,Francis S. Collins +9 more
TL;DR: The results suggest that treatment with FTIs represents a potential therapy for patients with HGPS, and hypothesized that retention of the farnesyl group causes progerin to become permanently anchored in the nuclear membrane, disrupting proper nuclear scaffolding and causing the characteristic nuclear blebbing seen in HGPS cells.