Brian E. Schwartz

TL;DR: A cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains is reported, establishing proof-of-concept for targeting protein–protein interactions of epigenetic ‘readers’, and providing a versatile chemical scaffold for the development of chemical probes more broadly throughout the b romodomain family.

TL;DR: It is concluded that H3.3 deposition is coupled to transcription, and continues while a gene is active, and repeated histone replacement suggests a mechanism to both maintain the structure of chromatin and access to DNA at active genes.

TL;DR: IHC staining with the C52 monoclonal antibody is a highly sensitive and specific test that reliably distinguishes NMC from other forms of carcinoma.

TL;DR: Flavopiridol, a highly specific P-TEFb kinase inhibitor, dramatically reduces the global levels of Ser2--but not Ser5--phosphorylated CTD at actively transcribed loci on Drosophila polytene chromosomes under both normal and heat shocked conditions.

TL;DR: Findings provide preclinical support for trials of HDACi in patients with NMC, and show that expression of BRD4-NUT is associated with globally decreased histone acetylation and transcriptional repression.