Brian G. Williams

TL;DR: The changing relationship between the causative agent, Mycobacterium tuberculosis, and its human host is reviewed and a range of factors that could explain the persistence of TB are examined.

TL;DR: Current models of untreated tuberculosis that assume a total duration of 2 years until self-cure or death underestimate the duration of disease by about one year, but their case fatality estimates of 70% for smear-positive and 20% for culture-positive smear-negative tuberculosis appear to be satisfactory.

TL;DR: In this article, the authors compared the predictions of several mathematical models simulating the same ART intervention programmes to determine the extent to which models agree about the epidemiological impact of expanded ART.

TL;DR: In a systematic review and meta-analysis, Amitabh Suthar and colleagues investigate the association between antiretroviral therapy and the reduction in the incidence of tuberculosis in adults with HIV infection.

TL;DR: In this article, the authors investigated the effect of case management programs on TB incidence and found that if TB diagnosis and treatment (including DOTS) are having a greater effect in countries where they have been most widely implemented, then conventional indicators of programme performance, including case detection and treatment success rates, should emerge as dominant explanatory variables in an ecologic or correlation analysis.