B
Brian Keegan
Researcher at Baylor College of Medicine
Publications - 31
Citations - 842
Brian Keegan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Adjuvant & Immunogenicity. The author has an hindex of 13, co-authored 26 publications receiving 725 citations. Previous affiliations of Brian Keegan include National Institutes of Health & Boston Children's Hospital.
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Journal ArticleDOI
Vaccination of Monkeys with Recombinant Plasmodium falciparum Apical Membrane Antigen 1 Confers Protection against Blood-Stage Malaria
Anthony W. Stowers,Michael C. Kennedy,Brian Keegan,Allan Saul,Carole A. Long,Louis H. Miller +5 more
TL;DR: The protection induced by a combination vaccine of AMA1 and MSP1 was not superior to the protection obtained with AMA1 alone, although the immunity generated appeared to operate against both vaccine components.
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Immunity to Recombinant Plasmodium falciparum Merozoite Surface Protein 1 (MSP1): Protection in Aotus nancymai Monkeys Strongly Correlates with Anti-MSP1 Antibody Titer and In Vitro Parasite-Inhibitory Activity
Sanjay Singh,Kazutoyo Miura,Hong Zhou,Olga Muratova,Brian Keegan,Aaron P. Miles,Laura B. Martin,Allan Saul,Louis H. Miller,Carole A. Long +9 more
TL;DR: The data indicate that the ELISA and GI assay values can significantly predict protective immunity induced by a blood-stage vaccine, and they support the use of these assays as part of evaluation of human clinical trials of MSP1-based vaccines.
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Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation.
TL;DR: The MP/OVA/CpG formulation produced a sustained and heightened humoral and cellular immune response, with an overall TH1 bias, while maintaining high levels of IgG1 antibody equivalent to that seen with Alhydrogel(®) adjuvant.
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Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections
Bin Zhan,Coreen M. Beaumier,Neima Briggs,Kathryn M. Jones,Brian Keegan,Maria Elena Bottazzi,Peter J. Hotez +6 more
TL;DR: A five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.
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A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease
Meagan A. Barry,Qian Wang,Kathryn M. Jones,Michael J. Heffernan,Munir H. Buhaya,Coreen M. Beaumier,Brian Keegan,Bin Zhan,Eric Dumonteil,Maria Elena Bottazzi,Peter J. Hotez +10 more
TL;DR: This is the first study demonstrating immunogenicity and efficacy of a therapeutic Chagas vaccine using a nanoparticle delivery system and a significant reduction in cardiac parasite burden and inflammatory cell infiltrate.