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Brian P. Conlon
Researcher at University of North Carolina at Chapel Hill
Publications - 41
Citations - 4690
Brian P. Conlon is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Staphylococcus aureus & Antibiotics. The author has an hindex of 19, co-authored 31 publications receiving 3673 citations. Previous affiliations of Brian P. Conlon include University College Dublin & Northeastern University.
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Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal ArticleDOI
Activated ClpP kills persisters and eradicates a chronic biofilm infection
Brian P. Conlon,Ernesto S. Nakayasu,Ernesto S. Nakayasu,Laura E. Fleck,Michael D. LaFleur,Vincent M. Isabella,Ken Coleman,Steven N. Leonard,Richard D. Smith,Joshua N. Adkins,Kim Lewis +10 more
TL;DR: It is shown that ADEP4-activated ClpP becomes a fairly nonspecific protease and kills persisters by degrading over 400 proteins, forcing cells to self-digest, indicating a general principle for killing dormant cells—activation and corruption of a target, rather than conventional inhibition.
Journal ArticleDOI
Persister formation in Staphylococcus aureus is associated with ATP depletion.
Brian P. Conlon,Sarah E. Rowe,Autumn Brown Gandt,Austin S. Nuxoll,Niles P. Donegan,Eliza A. Zalis,Geremy Clair,Joshua N. Adkins,Ambrose L. Cheung,Kim Lewis +9 more
TL;DR: Cell sorting revealed that the expression of stationary markers is associated with a 100–1,000-fold increase in the likelihood of survival to antibiotic challenge and the adenosine triphosphate level of the cell is predictive of bactericidal antibiotic efficacy and explains bacterial tolerance to antibiotics.
Journal ArticleDOI
ATP-Dependent Persister Formation in Escherichia coli.
TL;DR: It is found that various stresses induce toxin-antitoxin (TA) expression but that induction of TAs does not necessarily increase persisters, and stochastic variation in ATP is the main mechanism of persister formation.
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Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease.
TL;DR: A review examines the importance of persister cells in chronic and relapsing S. aureus infections and proposes methods for their eradication.