B
Brian R. Holloway
Publications - 4
Citations - 467
Brian R. Holloway is an academic researcher. The author has contributed to research in topics: Ubiquitin & Tumor necrosis factor alpha. The author has an hindex of 1, co-authored 4 publications receiving 457 citations.
Papers
More filters
Journal ArticleDOI
Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α
TL;DR: TNF-α treatment of differentiated myotubes stimulated time- and concentration-dependent reductions in total protein content and loss of adult myosin heavy chain (MHCf) content; these changes were evident at low TNF- α concentrations that did not alter muscle DNA content and were not associated with a decrease in MHCf synthesis.
Journal ArticleDOI
Clenbuterol is not an agonist of Na+ dependent creatine transport.
Patent
Screening assay for proteolysis inhibitors
Brian R. Holloway,Ian D. Waddell +1 more
TL;DR: In this paper, a method and an assay for specifically identifying inhibitors of muscle protein degradation, comprising using (i) ubiquitin, (ii) a human ubiquITin-carrier E1 protein and (iii) a (1, 2) human ubiquitized protein E2 protein, is presented, which is able to directly ubiquitinylate protein substrates and is expressed in skeletal and/or cardiac muscle.