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Brigitte A. Graf
Researcher at Manchester Metropolitan University
Publications - 24
Citations - 1432
Brigitte A. Graf is an academic researcher from Manchester Metropolitan University. The author has contributed to research in topics: Hoodia gordonii & Quercetin. The author has an hindex of 10, co-authored 23 publications receiving 1310 citations. Previous affiliations of Brigitte A. Graf include Robert Gordon University & United States Department of Agriculture.
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Journal ArticleDOI
Flavonols, flavones, flavanones, and human health: epidemiological evidence.
TL;DR: The totality of the available evidence on these flavonoids suggests a role in the prevention of cancer and cardiovascular disease, and further research is warranted, particularly in controlled clinical trials.
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Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs.
Wilhelmina Kalt,Jeffrey B. Blumberg,Jane E. McDonald,Melinda Vinqvist-Tymchuk,Sherry Fillmore,Brigitte A. Graf,Jennifer M O'Leary,Paul E. Milbury +7 more
TL;DR: The results suggest that anthocyanins can accumulate in tissues, including tissues beyond the blood-brain barrier, and may confer benefits in brain function, including vision.
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Rat Gastrointestinal Tissues Metabolize Quercetin
Brigitte A. Graf,Clement K. Ameho,Gregory G. Dolnikowski,Paul E. Milbury,Chung-Yen Chen,Jeffrey B. Blumberg +5 more
TL;DR: The unique pattern of quercetin metabolites in each GI tissue indicates extensive biotransformation before absorption and distribution in rats, suggesting that the in vivo bioactivity of quERCetin may be due to its metabolites.
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Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells.
TL;DR: Anthocyanins and other phenolics from bilberry upregulate the oxidative stress defense enzymes HO-1 and GST-pi in RPE, suggesting that they stimulate signal transduction pathways influencing genes controlled by the antioxidant response element.
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Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-4'-glucoside.
William Mullen,Brigitte A. Graf,Stuart Thomas Caldwell,Richard C. Hartley,Garry G. Duthie,Christine A Edwards,Michael E. J. Lean,Alan Crozier +7 more
TL;DR: The data demonstrate that quercetin-4'-glucoside, which is a major flavonol in onions, undergoes rapid and extensive metabolism in the intestine, and this appears not to be associated with transport across the gut wall into the blood stream.