Brigitte Kühnel

TL;DR: In insights into the role of alcohol consumption in the genetic architecture of hypertension, a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions is conducted.

TL;DR: The results of this study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers.

TL;DR: A long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction is identified and it is shown that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.

TL;DR: A high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry is carried out, identifying 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation.

TL;DR: This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in ery throatcyte measures, and identifies 23 loci significantly associated with these traits.