B
Britta Vogel
Researcher at Heidelberg University
Publications - 32
Citations - 2289
Britta Vogel is an academic researcher from Heidelberg University. The author has contributed to research in topics: Zebrafish & Positional cloning. The author has an hindex of 18, co-authored 32 publications receiving 2030 citations.
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Journal ArticleDOI
Atlas of the clinical genetics of human dilated cardiomyopathy
Jan Haas,Karen S. Frese,Barbara Peil,Wanda Kloos,Andreas Keller,Rouven Nietsch,Zhu Feng,Sabine Müller,Elham Kayvanpour,Britta Vogel,Farbod Sedaghat-Hamedani,Wei Keat Lim,Xiaohong Zhao,Dmitriy Fradkin,Doreen Köhler,Simon Fischer,Jennifer Franke,Sabine Marquart,Ioana Barb,Daniel Tian Li,Ali Amr,Philipp Ehlermann,Derliz Mereles,Tanja Weis,Sarah Hassel,Andreas Kremer,Vanessa King,Emil Wirsz,Emil Wirsz,Richard Isnard,Michel Komajda,Alessandra Serio,Maurizia Grasso,Petros Syrris,Eleanor Wicks,Vincent Plagnol,Luis R. Lopes,Tenna Gadgaard,Hans Eiskjær,Mads E. Jørgensen,Diego García-Giustiniani,Martin Ortiz-Genga,María G. Crespo-Leiro,Rondal H Lekanne Dit Deprez,Imke Christiaans,Ingrid A.W. van Rijsingen,Arthur A.M. Wilde,Anders Waldenström,Martino Bolognesi,Riccardo Bellazzi,Stellan Mörner,Justo Lorenzo Bermejo,Lorenzo Monserrat,Eric Villard,Jens Mogensen,Yigal M. Pinto,Philippe Charron,Perry M. Elliott,Eloisa Arbustini,Hugo A. Katus,Benjamin Meder +60 more
TL;DR: This is to the authors' knowledge, the first study that comprehensively investigated the genetics of DCM in a large-scale cohort and across a broad gene panel of the known DCM genes and underline the high analytical quality and feasibility of Next-Generation Sequencing in clinical genetic diagnostics.
Journal ArticleDOI
Toward the blood-borne miRNome of human diseases
Andreas Keller,Petra Leidinger,Andrea S. Bauer,Abdou ElSharawy,Jan Haas,Christina Backes,Anke Wendschlag,Nathalia Giese,Christine Tjaden,Katja Ott,Jens Werner,Thilo Hackert,Klemens Ruprecht,Hanno Huwer,Junko Huebers,Gunnar Jacobs,Philip Rosenstiel,Henrik Dommisch,Arne S. Schaefer,Joachim Müller-Quernheim,Bernd Wullich,Bastian Keck,Norbert Graf,Joerg Reichrath,Britta Vogel,Almut Nebel,Sven Uwe Jager,Peer F Staehler,Ioannis Amarantos,Valesca Boisguerin,Cord F Staehler,Markus Beier,Matthias Scheffler,Markus W. Büchler,J Wischhusen,Sebastian F M Haeusler,Johannes Dietl,Sylvia Hofmann,Hans-Peter Lenhof,Stefan Schreiber,Hugo A. Katus,Wolfgang Rottbauer,Benjamin Meder,Joerg Hoheisel,Andre Franke,Eckart Meese +45 more
TL;DR: In a multicenter study, the expression profiles of 863 microRNAs were determined by array analysis of 454 blood samples from human individuals with different cancers or noncancer diseases, and this 'miRNome' was validated by quantitative real-time PCR.
Journal ArticleDOI
MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction
Benjamin Meder,Andreas Keller,Britta Vogel,Jan Haas,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Steffen Just,Anne Borries,Jessica Rudloff,Petra Leidinger,Eckart Meese,Hugo A. Katus,Wolfgang Rottbauer,Wolfgang Rottbauer +13 more
TL;DR: This study assessed here for the first time whole-genome miRNA expression in peripheral total blood samples of patients with acute myocardial infarction and identified 121 miRNAs, which are significantly dysregulated in AMI patients in comparison to healthy controls.
Journal ArticleDOI
Alterations in cardiac DNA methylation in human dilated cardiomyopathy
Jan Haas,Karen S. Frese,Yoon Jung Park,Yoon Jung Park,Andreas Keller,Britta Vogel,Anders Lindroth,Dieter Weichenhan,Jennifer Franke,Simon Fischer,Andrea S. Bauer,Sabine Marquart,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Doreen Köhler,Nadine M. Wolf,Sarah Hassel,Rouven Nietsch,Thomas Wieland,Philipp Ehlermann,Jobst Hendrik Schultz,Andreas Dösch,Derliz Mereles,Stefan E. Hardt,Johannes Backs,Jörg D. Hoheisel,Christoph Plass,Christoph Plass,Hugo A. Katus,Benjamin Meder +29 more
TL;DR: DNA methylation differences in pathways related to heart disease, but also in genes with yet unknown function in DCM or heart failure are detected, namely Lymphocyte antigen 75 (LY75), Tyrosine kinase‐type cell surface receptor HER3 (ERBB3), Homeobox B13 (HOXB13) and Adenosine receptor A2A (ADORA2A).
Journal ArticleDOI
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Benjamin Meder,Frank Rühle,Tanja Weis,Georg Homuth,Andreas Keller,Jennifer Franke,Barbara Peil,Justo Lorenzo Bermejo,Karen S. Frese,Andreas Huge,Anika Witten,Britta Vogel,Jan Haas,Uwe Völker,Florian Ernst,Alexander Teumer,Philipp Ehlermann,Christian Zugck,Frauke Friedrichs,Heyo K. Kroemer,Marcus Dörr,Wolfgang Hoffmann,Bernhard Maisch,Sabine Pankuweit,Volker Ruppert,Thomas Scheffold,Uwe Kühl,H.P. Schultheiss,Reinhold Kreutz,Georg Ertl,Christiane E. Angermann,Philippe Charron,Eric Villard,Françoise Gary,Richard Isnard,Michel Komajda,Matthias Lutz,Thomas Meitinger,Moritz F. Sinner,Moritz F. Sinner,Moritz F. Sinner,H.-Erich Wichmann,Michael Krawczak,Boris Ivandic,Dieter Weichenhan,Goetz Gelbrich,Nour Eddine El-Mokhtari,Stefan Schreiber,Stephan B. Felix,Gerd Hasenfuß,Arne Pfeufer,Norbert Hubner,Stefan Kääb,Eloisa Arbustini,Wolfgang Rottbauer,Wolfgang Rottbauer,Norbert Frey,Norbert Frey,Monika Stoll,Hugo A. Katus +59 more
TL;DR: The present study reveals a novel genetic susceptibility locus that clearly underlines the role of genetically driven, inflammatory processes in the pathogenesis of idiopathic DCM.