B
Britta Weigelt
Researcher at London Research Institute
Publications - 142
Citations - 13781
Britta Weigelt is an academic researcher from London Research Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 46, co-authored 73 publications receiving 12649 citations. Previous affiliations of Britta Weigelt include Netherlands Cancer Institute & University of Toronto.
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Journal ArticleDOI
Breast cancer metastasis: markers and models
TL;DR: New molecular technologies, such as DNA microarrays, support the idea that metastatic capacity might be an inherent feature of breast tumours and have important implications for prognosis predicition and the understanding of metastasis.
Journal ArticleDOI
Concordance among Gene-Expression–Based Predictors for Breast Cancer
Cheng Fan,Daniel S. Oh,Lodewyk F. A. Wessels,Britta Weigelt,Dimitry S.A. Nuyten,Andrew B. Nobel,Laura J. van't Veer,Charles M. Perou +7 more
TL;DR: Four of the five gene sets used for prognostication in patients with breast cancer showed significant agreement in the outcome predictions for individual patients and are probably tracking a common set of biologic phenotypes.
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway
Katrien Berns,E. Marielle Hijmans,Jasper Mullenders,Thijn R. Brummelkamp,Arno Velds,Mike Heimerikx,Ron M. Kerkhoven,Mandy Madiredjo,Wouter Nijkamp,Britta Weigelt,Reuven Agami,Wei Ge,Guy Cavet,Peter S. Linsley,Roderick L. Beijersbergen,René Bernards +15 more
TL;DR: The construction of a set of retroviral vectors encoding 23,742 distinct shRNAs, which target 7,914 different human genes for suppression, is reported, which confers resistance to both p53-dependent and p19ARF-dependent proliferation arrest, and abolishes a DNA-damage-induced G1 cell-cycle arrest.
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Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
Sunil Badve,David J. Dabbs,Stuart J. Schnitt,Frederick L. Baehner,Thomas Decker,Vincenzo Eusebi,Stephen B. Fox,Shu Ichihara,Jocelyne Jacquemier,Sunil R. Lakhani,José Palacios,Emad A. Rakha,Andrea L. Richardson,Fernando Schmitt,Puay Hoon Tan,Gary Tse,Britta Weigelt,Ian O. Ellis,Jorge S. Reis-Filho +18 more
TL;DR: The purpose of this article was to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.
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Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas.
Bas Kreike,Marieke van Kouwenhove,Hugo M. Horlings,Britta Weigelt,Hans Peterse,Harry Bartelink,Marc J. van de Vijver +6 more
TL;DR: Triple-negative tumors are synonymous with basal-like tumors, and can be identified by immunohistochemistry, based on gene-expression profiling, which revealed five distinct subgroups of triple-negative breast cancers.