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Bruce K. Tan
Researcher at Northwestern University
Publications - 200
Citations - 13615
Bruce K. Tan is an academic researcher from Northwestern University. The author has contributed to research in topics: Nasal polyps & Sinusitis. The author has an hindex of 42, co-authored 174 publications receiving 11374 citations. Previous affiliations of Bruce K. Tan include National Institutes of Health & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Stromal gene signatures in large-B-cell lymphomas
Georg Lenz,George E. Wright,Sandeep S. Dave,Wenming Xiao,Jonathan D. Powell,Hong Zhao,Weihong Xu,Bruce K. Tan,Neta Goldschmidt,Javeed Iqbal,Julie M. Vose,Martin Bast,Kai Fu,Dennis D. Weisenburger,Timothy C. Greiner,James O. Armitage,Alastair H. Kyle,Lorraine May,Randy D. Gascoyne,Joseph M. Connors,Gunhild Trøen,Harald Holte,Stein Kvaløy,Daan Dierickx,Gregor Verhoef,Jan Delabie,Erlend B. Smeland,Pedro Jares,A. Martinez,Armando López-Guillermo,Emili Montserrat,Elias Campo,Rita M. Braziel,Thomas P. Miller,Lisa M. Rimsza,James R. Cook,Brad Pohlman,John Sweetenham,Raymond R. Tubbs,Richard I. Fisher,Elena Hartmann,Andreas Rosenwald,German Ott,German Ott,H-K Muller-Hermelink,D Wrench,T. A. Lister,Elaine S. Jaffe,Wyndham H. Wilson,Wing C. Chan,Louis M. Staudt +50 more
TL;DR: Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment, and a multivariate model created from three gene-expression signatures predicted survival both in patients who received CHOP and patients who receive R-CHOP.
Journal ArticleDOI
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
Sandeep S. Dave,George E. Wright,Bruce K. Tan,Andreas Rosenwald,Andreas Rosenwald,Randy D. Gascoyne,Wing C. Chan,Richard I. Fisher,Rita M. Braziel,Lisa M. Rimsza,Thomas M. Grogan,Thomas P. Miller,Michael LeBlanc,Timothy C. Greiner,Dennis D. Weisenburger,James C. Lynch,Julie M. Vose,James O. Armitage,Erlend B. Smeland,Stein Kvaløy,Harald Holte,Jan Delabie,Joseph M. Connors,Peter M. Lansdorp,Qin Ouyang,T. Andrew Lister,Andrew Davies,Andrew J. Norton,H. Konrad Muller-Hermelink,German Ott,Elias Campo,Emilio Montserrat,Wyndham H. Wilson,Elaine S. Jaffe,Richard M. Simon,Liming Yang,John Powell,Hong Zhao,Neta Goldschmidt,Michael Chiorazzi,Louis M. Staudt +40 more
TL;DR: The length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis.
Journal ArticleDOI
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
Arthur L. Shaffer,Miriam Shapiro-Shelef,Neal N. Iwakoshi,Ann-Hwee Lee,Shu-Bing Qian,Hong Zhao,Xin Yu,Liming Yang,Bruce K. Tan,Andreas Rosenwald,Elaine M. Hurt,Emmanuel Petroulakis,Nahum Sonenberg,Jonathan W. Yewdell,Kathryn Calame,Laurie H. Glimcher,Louis M. Staudt +16 more
TL;DR: XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells, and upregulates genes encoding many secretory pathway components.
Journal ArticleDOI
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
George E. Wright,Bruce K. Tan,Andreas Rosenwald,Elaine H. Hurt,Adrian Wiestner,Louis M. Staudt +5 more
TL;DR: The ability of this gene expression-based predictor to classify DLBCLs into biologically and clinically distinct subgroups irrespective of the method used to measure gene expression is demonstrated.
Journal ArticleDOI
Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
Christina M. Annunziata,R. Eric Davis,Yulia N. Demchenko,William T. Bellamy,Ana Gabrea,Fenghuang Zhan,Georg Lenz,Ichiro Hanamura,George E. Wright,Wenming Xiao,Sandeep S. Dave,Elaine M. Hurt,Bruce K. Tan,Hong Zhao,Owen W. Stephens,Madhumita Santra,David R. Williams,Lenny Dang,Bart Barlogie,John D. Shaughnessy,W. Michael Kuehl,Louis M. Staudt +21 more
TL;DR: It is demonstrated that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta inhibitors hold promise for the treatment of this disease.