Showing papers by "Bruce M. Spiegelman published in 1979"

TL;DR: Major changes in the structure and location of microtubule initiation sites occur during the differentiation of neuroblastoma cells, and similar changes are likely to be involved in alterations in the morphology of other cell types.

TL;DR: It appears that at least three distinct classes of initiation sites can be observed in mammalian cells: primary sites, which regrow microtubules first after griseofulvin treatment; secondary sites,Which are distinct perinuclear sites and recover from griseoskeletal treatment more slowly than the primary sites; and tertiary sites or sites of growth of single microtubule, also located near the cell nucleus.

TL;DR: The similarities of the T polypeptides from the three sources studied imply that T is a widely distributed and conserved microtubule protein, and the similarities between the high molecular weight associated proteins from hog brain and mouse fibroblast suggest that they, too, are widely distributed.