Bruce M. Spiegelman

TL;DR: It is shown that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment, indicating that PRDM 16 and beige fat cells are required for the "browning" of white fat and the healthful effects of sub cutaneous adipose tissue.

TL;DR: This work aims to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.

TL;DR: The identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure, which links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases.

TL;DR: PPAR gamma ligands such as thiazolidinediones and RXR-specific retinoids may be useful therapeutic agents for the treatment of liposarcoma, suggesting that the differentiation block in these cells can be overcome by maximal activation of the PPAR pathway.

TL;DR: It is shown that the PGC-1α promoter is regulated by both CaMKIV and CnA activity, implying a unified pathway, integrating key regulators of calcium signaling with the transcriptional switch P GC-1 α, contributing to the relatively stable nature of muscle fiber-type determination.