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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Zoltan Arany,Huamei He,Jiandie D. Lin,Kirsten Hoyer,Christoph Handschin,Okan Toka,Ferhaan Ahmad,Takashi Matsui,Sherry Chin,Pei Hsuan Wu,Igor I. Rybkin,John M. Shelton,Monia Manieri,Saverio Cinti,Frederick J. Schoen,Rhonda S Bassel-Duby,Anthony Rosenzweig,Joanne S. Ingwall,Bruce M. Spiegelman +18 more
TL;DR: Using genetic knockout mice, it is shown that, while PGC-1alpha KO mice appear to retain normal mitochondrial volume in both muscle beds, expression of genes of oxidative phosphorylation is markedly blunted, indicating that P GC-1 alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli.
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PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein
TL;DR: It is shown that PPARγ ligands require full agonism to induce a brown fat gene program preferentially in subcutaneous white adipose cells, and that compounds that stabilize PRDM16 protein may represent a plausible therapeutic pathway for the treatment of obesity and diabetes.
Journal ArticleDOI
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
Antonio Vidal-Puig,Mercedes Jimenez-Linan,Bradford B. Lowell,Andreas Hamann,E Hu,Bruce M. Spiegelman,Jeffrey S. Flier,David E. Moller +7 more
TL;DR: PPAR gamma 2 mRNA expression is most abundant in adipocytes in normal mice, but lower level expression is seen in skeletal muscle, which demonstrates in vivo modulation of PPAR gamma mRNA levels over a fourfold range and provide an additional level of regulation for the control of adipocyte development and function.
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Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha
TL;DR: The results demonstrate that a developmental switch between these two related but highly specialized cell types can be controlled by the expression of key adipogenic transcription factors.
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Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Shingo Kajimura,Patrick Seale,Kazuishi Kubota,Elaine P. Lunsford,John V. Frangioni,Steven P. Gygi,Bruce M. Spiegelman +6 more
TL;DR: It is shown that PRDM16 forms a transcriptional complex with the active form of C/EBP-β (also known as LAP), acting as a critical molecular unit that controls the cell fate switch from myoblastic precursors to brown fat cells.