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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
TL;DR: The results suggest that VEGF mRNA levels are closely linked to the process of cellular differentiation; they clearly demonstrate that expression of this angiogenic factor is specifically regulated in a transformed cell line, possibly via aberrant activation of cellular second messenger pathways.
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A Smooth Muscle-Like Origin for Beige Adipocytes
Jonathan Z. Long,Katrin J. Svensson,Linus T.-Y. Tsai,Xing Zeng,Hyun Cheol Roh,Xingxing Kong,Rajesh R. Rao,Jesse Lou,Isha A. Lokurkar,Wendy Baur,John J. Castellot,Evan D. Rosen,Bruce M. Spiegelman +12 more
TL;DR: This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes.
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Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve
Kathleen S. Cook,Hye Yeong Min,David W. Johnson,Robert J. Chaplinsky,Jeffrey S. Flier,Clayton R. Hunt,Bruce M. Spiegelman +6 more
TL;DR: Because of the apparent restriction of adipsin synthesis to tissues highly active in lipid metabolism, its presence in serum, and its modulation in altered metabolic states, this molecule may play a previously unrecognized role in systemic lipid metabolism or energy balance.
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Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
R.T. White,Deborah Damm,N Hancock,Barry S. Rosen,Bradford B. Lowell,Patricia Usher,Jeffrey S. Flier,Bruce M. Spiegelman +7 more
TL;DR: The data presented here, demonstrating the equivalence of human adipsin to complement factor D and its high level of expression in fat, suggest a previously unsuspected role for adipose tissue in immune system biology.
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Biological control through regulated transcriptional coactivators.
TL;DR: Quantitative control of coactivators allows the functional integration of multiple transcription factors and facilitates the formation of distinct biological programs, enabling outputs of particular pathways to be increased far more than would otherwise be possible.