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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Adipocyte P2 gene: Developmental expression and homology of 5'-flanking sequences among fat cell-specific genes
TL;DR: The results indicate that the aP2 gene contains sequence information necessary for differentiation-dependent expression in fat cells; common elements shared by adipocyte-specific genes may play a role in this process.
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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim,Christiane D. Wrann,Mark P. Jedrychowski,Sara Vidoni,Yukiko Kitase,Kenichi Nagano,Chuan Zhou,Joshua Chou,Virginia-Jeni A. Parkman,Scott J. Novick,Timothy S. Strutzenberg,Bruce D. Pascal,Phuong T. Le,Daniel J. Brooks,Alexander M. Roche,Kaitlyn K. Gerber,Laura Mattheis,Wei Chen,Hua Tu,Mary L. Bouxsein,Patrick R. Griffin,Roland Baron,Clifford J. Rosen,Lynda F. Bonewald,Bruce M. Spiegelman +24 more
TL;DR: Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity as discussed by the authors, however, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified.
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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
Edward T. Chouchani,Lawrence Kazak,Mark P. Jedrychowski,Gina Z. Lu,Brian K. Erickson,John Szpyt,Kerry A. Pierce,Dina Laznik-Bogoslavski,Ramalingam Vetrivelan,Clary B. Clish,Alan J. Robinson,Steve P. Gygi,Bruce M. Spiegelman +12 more
TL;DR: Mitochondrial ROS induction in brown adipose tissue is identified as a mechanism that supports UCP1-dependent thermogenesis and whole-body energy expenditure, which opens the way to improved therapeutic strategies for combating metabolic disorders.
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PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
Christoph Handschin,Yvonne M. Kobayashi,Sherry Chin,Patrick Seale,Kevin P. Campbell,Bruce M. Spiegelman +5 more
TL;DR: It is shown that neuregulin-stimulated phosphorylation of P GC-1α and GA-binding protein (GABP) allows recruitment of PGC-1 α to the GABP complex and enhances transcription of a broad neuromuscular junction gene program.
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Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis
Kai Ge,Mohamed Guermah,Chao-Xing Yuan,Chao-Xing Yuan,Mitsuhiro Ito,Annika E. Wallberg,Bruce M. Spiegelman,Robert G. Roeder +7 more
TL;DR: Data indicate that TRAP220 acts, via the TRAP complex, as a PPARγ2-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis).