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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Severely impaired adipsin expression in genetic and acquired obesity.
TL;DR: The data suggest a possible role for adipsin in the above-mentioned disordered metabolic states, and raise the possibility that adipin expression may be used to distinguish obesities that arise from certain genetic or metabolic defects from those that result from pure overfeeding.
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Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK
Melina Fan,James Rhee,Julie St-Pierre,Christoph Handschin,Pere Puigserver,Jiandie D. Lin,Sibylle Jäeger,Hediye Erdjument-Bromage,Paul Tempst,Bruce M. Spiegelman +9 more
TL;DR: P160 myb binding protein (p160MBP) is a powerful negative regulator of PGC-1alpha function and provide a molecular mechanism for the activation of P GC-1 alpha by p38 MAPK.
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RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
TL;DR: Induction of mitochondrial biogenesis through pharmacological or metabolic modulation of the PPAR/PGC-1alpha pathway promises to be an effective therapeutic approach for mitochondrial disorders.
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Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
Christoph Handschin,Cheol Soo Choi,Sherry Chin,Sheene Kim,Dan Kawamori,Amarnath J. Kurpad,Nicole Neubauer,Jiang Hu,Vamsi K. Mootha,Vamsi K. Mootha,Young-Bum Kim,Rohit N. Kulkarni,Gerald I. Shulman,Bruce M. Spiegelman +13 more
TL;DR: A causal role for muscle PGC-1alpha in maintenance of glucose homeostasis is illustrated and an unexpected cytokine-mediated crosstalk between skeletal muscle and pancreatic islets is highlighted.