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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
H + transport is an integral function of the mitochondrial ADP/ATP carrier
Ambre M. Bertholet,Edward T. Chouchani,Lawrence Kazak,Alessia Angelin,Andriy Fedorenko,Jonathan Z. Long,Sara Vidoni,Ryan Garrity,Joonseok Cho,Naohiro Terada,Douglas C. Wallace,Bruce M. Spiegelman,Yuriy Kirichok +12 more
TL;DR: This work records AAC currents directly from inner mitochondrial membranes from various mouse tissues and identifies two distinct transport modes: ADP/ATP exchange and H+ transport, which suggests that the H+ leak and mitochondrial uncoupling could be dynamically controlled by cellular ATP demand and the rate ofADP/ ATP exchange.
Journal ArticleDOI
A Phase Ii Study of Troglitazone, an Activator of the Pparγ Receptor, in Patients with Chemotherapy-resistant Metastatic Colorectal Cancer
Matthew H. Kulke,George D. Demetri,Norman E. Sharpless,David P. Ryan,Ramesh A. Shivdasani,Jeffrey S. Clark,Bruce M. Spiegelman,Haesook T. Kim,Robert J. Mayer,Charles S. Fuchs +9 more
TL;DR: The treatment was well tolerated: no grade 3/4 treatment-related toxicities were observed, however, no objective tumor responses were noted, and all 25 patients had progressive disease as their best response to therapy.
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Posttranscriptional Control of Adipocyte Differentiation through Activation of Phosphoinositide 3-Kinase
Hiroshi Sakaue,Wataru Ogawa,Michihiro Matsumoto,Shoji Kuroda,Masafumi Takata,Tadanori Sugimoto,Bruce M. Spiegelman,Masato Kasuga +7 more
TL;DR: The results demonstrate that adipocyte differentiation is regulated at the posttranscriptional level and that activation of PI 3-kinase is required for this regulation.
Journal ArticleDOI
Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
TL;DR: The results indicate that the transcription of specific genes is increased during adipocyte differentiation and suggest that other levels of control, particularly mRNA stability, may contribute to the relative abundance of certain developmentally- regulated mRNAs in adipocytes.
Journal ArticleDOI
Cell biology of fat storage
Paul Cohen,Bruce M. Spiegelman +1 more
TL;DR: This review is intended to serve as an introduction to adipose cell biology and to familiarize the reader with how these cell types play a role in metabolic disease and, perhaps, as targets for therapeutic development.