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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Journal ArticleDOI
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
Srikripa Devarakonda,Kushol Gupta,Michael J. Chalmers,John F. Hunt,Patrick R. Griffin,Gregory D. Van Duyne,Bruce M. Spiegelman +6 more
TL;DR: These data show that PGC-1α2–220 undergoes a large-scale conformational change when binding to the ERRγLBD, leading to substantial compaction of the activation domain, which results in stable positioning of the N-terminal part of the activated domain, favorable for assembly of an active transcriptional complex.
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Cachexia and Brown Fat: A Burning Issue in Cancer
Serkan Kir,Bruce M. Spiegelman +1 more
TL;DR: Tumor-derived PTHrP has emerged as a key molecule playing multiple roles in cachexia, from fat "browning" factor to potential therapeutic target.
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Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation.
TL;DR: The results indicate that GPD gene expression is linked to cell differentiation in both fat and muscle cells, and suggest certain similarities in hormonal modulation in both cell types.
Journal ArticleDOI
Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes.
TL;DR: Insulin stimulates the secretion of a soluble protein, adipsin, as well as translocation to the plasma membrane of integral membrane proteins, including the glucose transporter, the transferrin receptors, and the insulin-like growth factor II receptor.
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Erratum: Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity (Cell Metabolism (2017) 26(4) (660–671.e3) (S1550413117304941)(10.1016/j.cmet.2017.08.009))
Lawrence Kazak,Edward T. Chouchani,Gina Z. Lu,Mark P. Jedrychowski,Curtis J. Bare,Amir I. Mina,Manju Kumari,Song Zhang,Ivan Vuckovic,Dina Laznik-Bogoslavski,Petras P. Dzeja,Alexander S. Banks,Evan D. Rosen,Bruce M. Spiegelman +13 more