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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Book ChapterDOI
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Jeffrey S. Flier,Brad Lowell,Antonella Napolitano,Patricia Usher,Barry S. Rosen,Kathleen S. Cook,Bruce M. Spiegelman +6 more
TL;DR: It is highlighted that an altered function of the cell, such as increased synthesis of lipoprotein lipase, might, under some circumstances, promote the storage of energy as fat.
Journal ArticleDOI
Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.
Hua Lin,Jonathan Z. Long,Alexander M. Roche,Katrin J. Svensson,Florence Y. Dou,Mi Ra Chang,Timothy S. Strutzenberg,Claudia Ruiz,Michael D. Cameron,Scott J. Novick,Charles A. Berdan,Sharon M. Louie,Daniel K. Nomura,Bruce M. Spiegelman,Patrick R. Griffin,Theodore M. Kamenecka +15 more
TL;DR: It is found that administration of N-acyl amino acids to mice improves glucose homeostasis and increases energy expenditure, indicating that this pathway might be useful for treating obesity and associated disorders.
Journal ArticleDOI
Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha.
Journal Article
A direct role for c-fos in AP-1-dependent gene transcription.
Roman Herrera,Sadhana Agarwal,K Walton,Brett Satterberg,Robert J. Distel,Richard H. Goodman,Bruce M. Spiegelman,Thomas M. Roberts +7 more
TL;DR: Experimental results indicate that c-fos and c-jun proteins are required to reconstitute full AP-1-dependent transcriptional activation and directly demonstrate that c -fos is a regulator of gene expression.
Posted ContentDOI
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3
Jessica A. Hall,Deepti Ramachandran,Hyun Cheol Roh,Joanna R. DiSpirito,T. Belchior de Oliveira,Peter-James H. Zushin,Colin J Palmer,Shangyu Hong,Amir Mina,Bingyang Liu,Zhaoming Deng,Pratik Aryal,Christopher Jacobs,Daniel G. Tenen,Chester W. Brown,Julia F. Charles,Gerald I. Shulman,Barbara B. Kahn,Linus T.-Y. Tsai,Evan D. Rosen,Bruce M. Spiegelman,Alexander S. Banks +21 more
TL;DR: It is shown that mice encoding an allele of PPARγ which cannot be phosphorylated at S273 are protected from insulin resistance, without exhibiting differences in body weight or TZD-associated side effects, and hyperinsulinemic-euglycemic clamp experiments confirm improved insulin sensitivity.