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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Patent
Compositions and methods for brown fat induction and activity using fndc5
TL;DR: In this article, the authors provide compositions and methods for brown fat induction and activity through modulation of Fndc5 activity and/or expression, and also provide methods for preventing or treating metabolic disorders in a subject.
Patent
PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
TL;DR: In this article, isolated nucleic acid molecules, designated PGC-1β nucleic acids molecules, which encode novel PGC 1 related coactivator molecules were provided, and diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
Journal ArticleDOI
SnapShot: Regulation and biology of PGC-1α
TL;DR: The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes as mentioned in this paper .
Patent
Novel FDRG protein and nucleic acid molecules and uses therefor
TL;DR: In this paper, a novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed, along with diagnostic, screening and therapeutic methods utilizing compositions of the invention.
Journal ArticleDOI
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Evanna L. Mills,Zeynep Gümüş Demir,Cathal Harmon,Cathal Harmon,Mark P. Jedrychowski,Haopeng Xiao,Anja V. Gruszczyk,Gary A. Bradshaw,Nhien Tran,Ryan Garrity,Dina Laznik-Bogoslavski,John Szpyt,Hannah Prendeville,Lydia Lynch,Lydia Lynch,Lydia Lynch,Michael P. Murphy,Steven P. Gygi,Bruce M. Spiegelman,Edward T. Chouchani +19 more
TL;DR: In this article, the UCP1 C253 activation site was found to be a major regulator of acute thermogenesis and sex-dependent tissue inflammation in both males and females, but showed no measurable effect on fat accumulation in an obesogenic environment.