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Bruce M. Spiegelman
Researcher at Harvard University
Publications - 443
Citations - 172265
Bruce M. Spiegelman is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Transcription factor. The author has an hindex of 179, co-authored 434 publications receiving 158009 citations. Previous affiliations of Bruce M. Spiegelman include University of California, San Francisco & Vassar College.
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Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science
TL;DR: Dr Se-Jin Lee is responsible for the discovery of myostatin, a critical regulator of skeletal muscle mass and function and has characterized additional transforming growth factor–β family members acting in this pathway.
Posted ContentDOI
Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner
Xingxing Kong,Peng Zhou,Ting Yao,Lawrence Kazak,Danielle Tenen,Anna Lyubetskaya,Brian A. Dawes,Linus T.-Y. Tsai,Barbara B. Kahn,Bruce M. Spiegelman,Tiemin Liu,Evan D. Rosen +11 more
TL;DR: Mice lacking IRF4 in BAT have a decrease in exercise capacity, accompanied by histological, ultrastructural, signaling, gene expression, and bioenergetic evidence of myopathy in white vastus, pointing to an unsuspected level of BAT-muscle cross-talk driven by IRF 4 and myostatin.