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Bruce R. Southey

Bio: Bruce R. Southey is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Prohormone & Transcriptome. The author has an hindex of 30, co-authored 94 publications receiving 5438 citations.


Papers
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Journal ArticleDOI
Martien A. M. Groenen1, Alan Archibald2, Hirohide Uenishi, Christopher K. Tuggle3, Yasuhiro Takeuchi4, Max F. Rothschild3, Claire Rogel-Gaillard5, Chankyu Park6, Denis Milan7, Hendrik-Jan Megens1, Shengting Li8, Denis M. Larkin9, Heebal Kim10, Laurent A. F. Frantz1, Mario Caccamo11, Hyeonju Ahn10, Bronwen Aken12, Anna Anselmo13, Christian Anthon14, Loretta Auvil15, Bouabid Badaoui13, Craig W. Beattie16, Christian Bendixen8, Daniel Berman17, Frank Blecha18, Jonas Blomberg19, Lars Bolund8, Mirte Bosse1, Sara Botti13, Zhan Bujie8, Megan Bystrom3, Boris Capitanu15, Denise Carvalho-Silva20, Patrick Chardon5, Celine Chen21, Ryan Cheng3, Sang-Haeng Choi, William Chow12, Richard Clark12, C M Clee12, Richard P. M. A. Crooijmans1, Harry D. Dawson21, Patrice Dehais7, Fioravante De Sapio2, Bert Dibbits1, Nizar Drou11, Zhi-Qiang Du3, Kellye Eversole, João Fadista8, João Fadista22, Susan Fairley12, Thomas Faraut7, Geoffrey J. Faulkner2, Geoffrey J. Faulkner22, Katie E. Fowler23, Merete Fredholm14, Eric Fritz3, James G. R. Gilbert12, Elisabetta Giuffra5, Elisabetta Giuffra13, Jan Gorodkin14, Darren K. Griffin23, Jennifer Harrow12, Alexander Hayward24, Kerstin Howe12, Zhi-Liang Hu3, Sean Humphray12, Sean Humphray22, Toby Hunt12, Henrik Hornshøj8, Jin-Tae Jeon25, Patric Jern24, Matthew Jones12, Jerzy Jurka26, Hiroyuki Kanamori, Ronan Kapetanovic2, Jaebum Kim15, Jaebum Kim6, Jae-Hwan Kim, Kyu-Won Kim, Tae-Hun Kim, Greger Larson27, Kyooyeol Lee6, Kyung-Tai Lee, Richard M. Leggett11, Harris A. Lewin28, Yingrui Li, Wan Sheng Liu29, Jane E. Loveland12, Yao Lu, Joan K. Lunney17, Jian Ma15, Ole Madsen1, Katherine M. Mann17, Katherine M. Mann22, Lucy Matthews12, Stuart McLaren12, Takeya Morozumi, Michael P. Murtaugh30, Jitendra Narayan9, Dinh Truong Nguyen6, Peixiang Ni, Song-Jung Oh31, Suneel Kumar Onteru3, Frank Panitz8, Eung-Woo Park, Hong-Seog Park, Géraldine Pascal32, Yogesh Paudel1, Miguel Pérez-Enciso, Ricardo H. Ramirez-Gonzalez11, James M. Reecy3, Sandra L. Rodriguez-Zas15, Gary A. Rohrer17, Lauretta A. Rund15, Yongming Sang18, Kyle M. Schachtschneider15, Joshua G. Schraiber33, John C. Schwartz30, Linda Scobie34, Carol Scott12, Stephen M. J. Searle12, Bertrand Servin7, Bruce R. Southey15, Göran O. Sperber19, Peter F. Stadler35, Jonathan V. Sweedler15, Hakim Tafer35, Bo Thomsen8, Rashmi Wali34, Jian Wang, Jun Wang14, Simon D. M. White12, Xun Xu, Martine Yerle7, Guojie Zhang, Jianguo Zhang, Jie Zhang36, Shuhong Zhao36, Jane Rogers11, Carol Churcher12, Lawrence B. Schook15 
15 Nov 2012-Nature
TL;DR: The assembly and analysis of the genome sequence of a female domestic Duroc pig and a comparison with the genomes of wild and domestic pigs from Europe and Asia reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago.
Abstract: For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.

1,189 citations

Journal ArticleDOI
24 Apr 2009-Science
TL;DR: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage and provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

1,144 citations

Journal ArticleDOI
01 Apr 2010-Nature
TL;DR: This work shows that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets and shows evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience.
Abstract: The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.

837 citations

Journal ArticleDOI
05 Jun 2015-Science
TL;DR: There is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings and these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements.
Abstract: The evolution of eusociality is one of the major transitions in evolution, but the underlying genomic changes are unknown We compared the genomes of 10 bee species that vary in social complexity, representing multiple independent transitions in social evolution, and report three major findings First, many important genes show evidence of neutral evolution as a consequence of relaxed selection with increasing social complexity Second, there is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings Third, though clearly independent in detail, these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements Eusociality may arise through different mechanisms each time, but would likely always involve an increase in the complexity of gene networks

325 citations

Journal ArticleDOI
TL;DR: It is shown that aggression-related genes with inherited patterns of brain expression are also environmentally regulated, and it appears that one element in the evolution of different degrees of aggressive behavior in honey bees involved changes in regulation of genes that mediate the response to alarm pheromone.
Abstract: A prominent theory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent to which this theory holds true for behavioral evolution is not known. Because "nature and nurture" are now understood to involve hereditary and environmental influences on gene expression, we studied whether environmental influences on a behavioral phenotype, i.e., aggression, could have evolved into inherited differences via changes in gene expression. Here, with microarray analysis of honey bees, we show that aggression-related genes with inherited patterns of brain expression are also environmentally regulated. There were expression differences in the brain for hundreds of genes between the highly aggressive Africanized honey bee compared with European honey bee (EHB) subspecies. Similar results were obtained for EHB in response to exposure to alarm pheromone (which provokes aggression) and when comparing old and young bees (aggressive tendencies increase with age). There was significant overlap of the gene lists generated from these three microarray experiments. Moreover, there was statistical enrichment of several of the same cis regulatory motifs in promoters of genes on all three gene lists. Aggression shows a remarkably robust brain molecular signature regardless of whether it occurs because of inherited, age-related, or environmental (social) factors. It appears that one element in the evolution of different degrees of aggressive behavior in honey bees involved changes in regulation of genes that mediate the response to alarm pheromone.

253 citations


Cited by
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28 Jul 2005
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

18,940 citations

Journal ArticleDOI
06 Jun 1986-JAMA
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Abstract: I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

7,563 citations

01 Jan 2010
TL;DR: In this paper, the authors describe a scenario where a group of people are attempting to find a solution to the problem of "finding the needle in a haystack" in the environment.
Abstract: 中枢神経系疾患の治療は正常細胞(ニューロン)の機能維持を目的とするが,脳血管障害のように機能障害の原因が細胞の死滅に基づくことは多い.一方,脳腫瘍の治療においては薬物療法や放射線療法といった腫瘍細胞の死滅を目標とするものが大きな位置を占める.いずれの場合にも,細胞死の機序を理解することは各種病態や治療法の理解のうえで重要である.現在のところ最も研究の進んでいる細胞死の型はアポトーシスである.そのなかで重要な位置を占めるミトコンドリアにおける反応および抗アポトーシス因子について概要を紹介する.

2,716 citations

Journal ArticleDOI
Erich D. Jarvis1, Siavash Mirarab2, Andre J. Aberer3, Bo Li4, Bo Li5, Bo Li6, Peter Houde7, Cai Li6, Cai Li4, Simon Y. W. Ho8, Brant C. Faircloth9, Benoit Nabholz, Jason T. Howard1, Alexander Suh10, Claudia C. Weber10, Rute R. da Fonseca11, Jianwen Li, Fang Zhang Zhang, Hui Li, Long Zhou, Nitish Narula7, Nitish Narula12, Liang Liu13, Ganesh Ganapathy1, Bastien Boussau, Shamsuzzoha Bayzid2, Volodymyr Zavidovych1, Sankar Subramanian14, Toni Gabaldón15, Salvador Capella-Gutierrez, Jaime Huerta-Cepas, Bhanu Rekepalli16, Bhanu Rekepalli17, Kasper Munch18, Mikkel H. Schierup18, Bent E. K. Lindow11, Wesley C. Warren19, David A. Ray, Richard E. Green20, Michael William Bruford21, Xiangjiang Zhan22, Xiangjiang Zhan21, Andrew Dixon, Shengbin Li5, Ning Li23, Yinhua Huang23, Elizabeth P. Derryberry24, Elizabeth P. Derryberry25, Mads F. Bertelsen26, Frederick H. Sheldon25, Robb T. Brumfield25, Claudio V. Mello27, Claudio V. Mello28, Peter V. Lovell28, Morgan Wirthlin28, Maria Paula Cruz Schneider27, Francisco Prosdocimi27, José Alfredo Samaniego11, Amhed Missael Vargas Velazquez11, Alonzo Alfaro-Núñez11, Paula F. Campos11, Bent O. Petersen29, Thomas Sicheritz-Pontén29, An Pas, Thomas L. Bailey, R. Paul Scofield30, Michael Bunce31, David M. Lambert14, Qi Zhou, Polina L. Perelman32, Amy C. Driskell33, Beth Shapiro20, Zijun Xiong, Yongli Zeng, Shiping Liu, Zhenyu Li, Binghang Liu, Kui Wu, Jin Xiao, Xiong Yinqi, Quiemei Zheng, Yong Zhang, Huanming Yang, Jian Wang, Linnéa Smeds10, Frank E. Rheindt34, Michael J. Braun35, Jon Fjeldså11, Ludovic Orlando11, F. Keith Barker4, Knud A. Jønsson4, Warren E. Johnson33, Klaus-Peter Koepfli33, Stephen J. O'Brien36, David Haussler, Oliver A. Ryder, Carsten Rahbek4, Eske Willerslev11, Gary R. Graves33, Gary R. Graves4, Travis C. Glenn13, John E. McCormack37, Dave Burt38, Hans Ellegren10, Per Alström, Scott V. Edwards39, Alexandros Stamatakis3, David P. Mindell40, Joel Cracraft4, Edward L. Braun41, Tandy Warnow42, Tandy Warnow2, Wang Jun, M. Thomas P. Gilbert31, M. Thomas P. Gilbert4, Guojie Zhang11, Guojie Zhang6 
12 Dec 2014-Science
TL;DR: A genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves recovered a highly resolved tree that confirms previously controversial sister or close relationships and identifies the first divergence in Neoaves, two groups the authors named Passerea and Columbea.
Abstract: To better determine the history of modern birds, we performed a genome-scale phylogenetic analysis of 48 species representing all orders of Neoaves using phylogenomic methods created to handle genome-scale data. We recovered a highly resolved tree that confirms previously controversial sister or close relationships. We identified the first divergence in Neoaves, two groups we named Passerea and Columbea, representing independent lineages of diverse and convergently evolved land and water bird species. Among Passerea, we infer the common ancestor of core landbirds to have been an apex predator and confirm independent gains of vocal learning. Among Columbea, we identify pigeons and flamingoes as belonging to sister clades. Even with whole genomes, some of the earliest branches in Neoaves proved challenging to resolve, which was best explained by massive protein-coding sequence convergence and high levels of incomplete lineage sorting that occurred during a rapid radiation after the Cretaceous-Paleogene mass extinction event about 66 million years ago.

1,624 citations