Bruce S. Hass

TL;DR: The current study provides the most structurally diverse ER RBA data set with the widest range of RBA values published to date.

TL;DR: The collaboration supplied a choice of healthy, long-lived rodent models to investigators, while allowing for the development of some of the most definitive information on life span, food consumption, and growth characteristics in these genotypes under diverse feeding paradigms.

TL;DR: An overall picture of how xenoestrogens structurally resemble endogenous 17beta-estradiol and the synthetic estrogen diethylstilbestrol is provided, which is rationalized into a set of hierarchical rules that will be useful in guidance for identification of potential estrogens.

TL;DR: Estrogen receptor relative binding affinities can be utilized before animal testing to rank order estimates of the potential for in vivo estrogenic activity of a wide range of untested plant chemicals (as well as other chemicals) based on ER binding.

TL;DR: It is concluded that the effects of CR treatment of the animal are transferred to individual cells and these responses are cellular and molecular analogs of in vivo weight loss, life extension, and carcinogenesis modulation, which are hallmarks of CR in the whole animal.