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Bruce W. Birren
Researcher at Broad Institute
Publications - 215
Citations - 125222
Bruce W. Birren is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 103, co-authored 205 publications receiving 113491 citations. Previous affiliations of Bruce W. Birren include Massachusetts Institute of Technology & California Institute of Technology.
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Journal ArticleDOI
Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone
Daniel J. Park,Gytis Dudas,Shirlee Wohl,Shirlee Wohl,Augustine Goba,Shannon L.M. Whitmer,Kristian G. Andersen,Rachel Sealfon,Rachel Sealfon,Jason T. Ladner,Jeffrey R. Kugelman,Christian B. Matranga,Sarah M. Winnicki,Sarah M. Winnicki,James Qu,Stephen K. Gire,Stephen K. Gire,Adrianne Gladden-Young,Simbirie Jalloh,Dolo Nosamiefan,Nathan L. Yozwiak,Nathan L. Yozwiak,Lina M. Moses,Pan Pan Jiang,Pan Pan Jiang,Aaron E. Lin,Aaron E. Lin,Stephen F. Schaffner,Stephen F. Schaffner,Brian H. Bird,Jonathan S. Towner,Mambu Mamoh,Michael Gbakie,Lansana Kanneh,David Kargbo,James L.B. Massally,Fatima K. Kamara,Edwin Konuwa,Josephine Sellu,Abdul A. Jalloh,Ibrahim Mustapha,Momoh Foday,Mohamed Yillah,Bobbie R. Erickson,Tara K. Sealy,Dianna M. Blau,Christopher D. Paddock,Aaron C. Brault,Brian R. Amman,Jane Basile,Scott W. Bearden,Jessica A. Belser,Eric Bergeron,Shelley Campbell,Ayan K. Chakrabarti,Kimberly A. Dodd,Mike Flint,Aridth Gibbons,Christin H. Goodman,John D. Klena,Laura K. Mcmullan,Laura Morgan,Brandy J. Russell,Johanna S. Salzer,Angela J. Sanchez,David Wang,Irwin Jungreis,Christopher Tomkins-Tinch,Andrey Kislyuk,Michael F. Lin,Sinéad B. Chapman,Bronwyn MacInnis,Ashley Matthews,Ashley Matthews,James Bochicchio,Lisa E. Hensley,Jens H. Kuhn,Chad Nusbaum,John S. Schieffelin,Bruce W. Birren,Marc Forget,Stuart T. Nichol,Gustavo Palacios,Daouda Ndiaye,Christian T. Happi,Sahr M. Gevao,Mohamed A. Vandi,Brima Kargbo,Edward C. Holmes,Trevor Bedford,Andreas Gnirke,Ute Ströher,Andrew Rambaut,Andrew Rambaut,Robert F. Garry,Pardis C. Sabeti,Pardis C. Sabeti +96 more
TL;DR: Analysis of sequences from 232 patients sampled over 7 months in Sierra Leone, along with 86 previously released genomes from earlier in the epidemic, confirms sustained human-to-human transmission within Sierra Leone and finds no evidence for import or export of EBOV across national borders after its initial introduction.
Journal ArticleDOI
Genomics of the fungal kingdom: Insights into eukaryotic biology
TL;DR: An overview of available fungal genomes is provided and some of the biological insights that have been derived through their analysis are highlighted, including insights into the fundamental cellular biology shared between fungi and other eukaryotic organisms.
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Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity
Molly OhAinle,Angel Balmaseda,Alexander R. Macalalad,Yolanda Tellez,Michael C. Zody,Saira Saborio,Andrea Nuñez,Niall Lennon,Bruce W. Birren,Aubree Gordon,Matthew R. Henn,Eva Harris +11 more
TL;DR: The data demonstrate that the complex interaction between viral genetics and population dynamics of serotype-specific immunity contributes to the risk of severe dengue disease and provide insights into viral evolution and the effects of a patient’s immunological background on viral fitness and virulence.
Journal ArticleDOI
The Complete Genome and Proteome of Mycoplasma mobile
Jacob D. Jaffe,Nicole Stange-Thomann,Cherylyn Smith,David DeCaprio,Sheila Fisher,Jonathan Butler,Sarah E. Calvo,Tim Elkins,Michael Fitzgerald,Nabil Hafez,Chinnappa D. Kodira,John E. Major,Shunguang Wang,Jane E. Wilkinson,Robert Nicol,Chad Nusbaum,Bruce W. Birren,Howard C. Berg,George M. Church +18 more
TL;DR: For the first time, proteomic data are used in the primary annotation of a new genome, providing validation of expression for many of the predicted proteins, including a long repeating unit of DNA of approximately 2435 bp present in five complete copies.
Journal ArticleDOI
How deep is deep enough for RNA-Seq profiling of bacterial transcriptomes?
TL;DR: The findings suggest that the number of reads typically produced in a single lane of the Illumina HiSeq sequencer far exceeds the number needed to saturate the annotated transcriptomes of diverse bacteria growing in monoculture.