Bruce W. Birren

TL;DR: The complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled from Vietnamese patients is determined and an episode of genotype replacement was observed, with Asian 1 lineage viruses entirely displacing the previously dominant Asian/American lineage viruses.

TL;DR: Recent intron dynamics do not support a model whereby 5′ intron positional bias is generated solely by 3′-biased intron loss, and a probabilistic model is developed to estimate the most likely rates of intron gain and loss giving rise to these observed conservation patterns.

TL;DR: The data support the hypothesis that the 2000 human listeriosis outbreak was caused by a L. monocytogenes strain that persisted in a food processing facility over 12 years and show that genome sequencing is a valuable and feasible tool for retrospective epidemiological analyses.

TL;DR: It is found that loss-of-function mutations in ald (Rv2780), encoding L-alanine dehydrogenase, were associated with unexplained drug resistance, and drug susceptibility testing established that ald loss of function conferred resistance to D-cycloserine, and susceptibility to the drug was partially restored by complementation of ald.

TL;DR: Comparison between physical and genetic maps revealed a striking difference in recombination rates between the sexes with a lower recombination frequency in males than females, which may enable a chromosomal misalignment at proximal and distal CMT1A-REPs and promote unequal crossing over, which occurs 10 times more frequently in male meiosis.