Medical diagnostic system, apparatus and methods are disclosed. Optical transmitters generate radiation-containing photons having a specific interaction with at least one target chromophore in a target structure, preferably a blood vessel such as the interior jugular vein. The optical transmitters transmit the radiation into at least a first area including a substantial portion of the target structure and into a second area not including a substantial portion of the target structure. Optical receivers detect a portion radiation scattered from at least the first area and the second area. A processor estimates oxygenation, pH or cardiac output based on the scattered radiation detected from the first area, and the scattered radiation from the second area.

Apparatus and method for non-invasive and minimally-invasive sensing of parameters relating to blood

A method for assaying a component of a localized region of interest in a body comprising: illuminating the region with at least one pulse of radiation having a wavelength at which the radiation is absorbed by the component to generate a change in an acoustic property of the region; transmitting ultrasound so that it is incident on the region; measuring at least one effect of the change on the incident ultrasound; using the measured at least one effect to determine an absorption coefficient for the radiation in the region; and using the determined absorption coefficient to determine concentration of the component in the region.

Photoacoustic assay and imaging system

Medical diagnostic apparatus and methods are disclosed. Ultrasound radiation pressure selectively modulates a target area within a body. One or more pulses of radiation containing temporally correlated groups of photons are generated. The photons are characterized by two or more different wavelengths that are selected to have specific interaction with a target chromophore. The two or more different wavelengths are also selected to have substantially similar scattering cross-sections and anisotropy parameters in the target and its surroundings. The pulses of radiation are injected into the body proximate the target area being modulated by the radiation pressure field. Photon groups at each of the different wavelengths that are backscattered from the target area are detected in temporal coincidence. Time-gated background-free amplification of the return signal is used to exclude photons which could not by virtue of their arrival time have interacted with the radiation-pressure-modulated target. Photon groups are selected with a modulation component at the modulation frequency of the radiation pressure modulation field, or at a harmonic of the modulation frequency. From the arrival rate of the detected temporally correlated photon pairs or multiplets, chemical information about the target area, such as an oxygenation or pH level can be inferred. Cardiac output may be computed from measurements of venous and/or arterial oxygenation using this technique.

Apparatus and method for non-invasive and minimally-invasive sensing of venous oxygen saturation and pH levels

Digital image data including discrete photographic images of a variety of different subjects, times, and so forth, are collected and analyzed to identify specific features in the photographs. In an embodiment of the invention, distinctive markers are distributed to aid in the identification of particular subject matter. Facial recognition may also be employed. The digital image data is maintained in a database and quarried in response to search requests. The search requests include criteria specifying any feature category or other identifying information, such as date, time, and location that each photograph was taken, associated with each photograph. Candidate images are provided for review by requesters, who may select desired images for purchase or downloading.

Method and apparatus for photograph finding

Apparatus and methods are provided for monitoring a parameter of a region of interest (ROI) within a first tissue type within a body. A control unit drives a measurement unit to provide an operating condition such that acoustic waves overlap with a region within the ROI that is illuminated by illuminating light such as to generate a first set of tagged photons, and such that the acoustic waves overlap with a region of tissue within a second tissue type that is illuminated by illuminating light such as to generate a second set of tagged photons, the first and second sets of tagged photons being distinguishable from one another. The control unit determines the parameter of the ROI by extracting data portions associated with, respectively, the light response of the ROI and the light response of the second tissue type, by distinguishing between the sets of tagged photons.

Method and apparatus for noninvasively monitoring parameters of a region of interest in a human body

A method and apparatus are presented for detecting an effect of interactions of electromagnetic radiation with ultrasound radiation at different locations within a region of interest in a scattering medium to thereby enable imaging of said medium. A plurality of sequences of pulses of ultrasound radiation is transmitted towards a plurality of locations, respectively, in said region of interest within an X-Y plane perpendicular to axes of propagation of the ultrasound pulses. Said region of interest is illuminated with incident electromagnetic radiation of at least one wavelength. The phases of the ultrasound radiation or the phases of the electromagnetic radiation components are appropriately controlled in order to be enable identification of the interactions between the electromagnetic and ultrasound radiation that occur at different locations along the Z-axis. Signals of the electromagnetic radiation, each being frequency modulated by a frequency of the ultrasound radiation, are detected, to thereby enabling the imaging of the region of interest.

Apparatus and method for probing light absorbing agents in biological tissues

Method and apparatus for determining the oxygenation level of hemoglobin in a probed region of the human body. A probed region of the body is irradiated with diffuse light, the frequency of which is shifted with ultrasound focused at the probed region. The relation between the two states of the oxygenation of the hemoglobin is determined by the light absorption at the focal region of the ultrasound. The blood volume may be monitored by irradiating the probed region with light at the isosbestic point.

Metabolism monitoring of body organs

A method and processing device are presented for reconstructing an absorption and/or scattering image of a region of interest inside a scattering medium. A mathematical model is provided being representative of a relation between the distribution of the intensity and phase of electromagnetic radiation components scattered from a medium and a certain attenuation factor, which is function of spatial variations of scattering and absorption coefficients of the medium. The mathematical is used for processing a map of distribution of the intensity of electromagnetic radiation components scattered from known locations within the region of interest, thereby producing a halftone pattern of the region of interest.

Bruno Gad Sfez

Papers

Apparatus and method for probing light absorbing agents in biological tissues

Metabolism monitoring of body organs

Method and apparatus for imaging absorbing objects in a scattering medium