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Bruno V. DePamphilis

Bio: Bruno V. DePamphilis is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Crystal structure & Square pyramidal molecular geometry. The author has an hindex of 3, co-authored 4 publications receiving 75 citations.

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TL;DR: In this article, the properties of TcOCl 4 O (4-x ) and Na[TcO(OCH 2 CH 2 O) 2 ] (2 ) have been determined by standard methods and refined to R 1 = 0.0694, R 2 =0.0613, on the basis of 2887 independent reflections.

35 citations

Journal ArticleDOI
TL;DR: In this article, the properties of TcOCl 4 O (4-x ) and Na[TcO(OCH 2 CH 2 O) 2 ] (2 ) have been determined by standard methods and refined to R 1 = 0.0694, R 2 =0.0613, on the basis of 2887 independent reflections.
Abstract: The complexes (Bu 4 N)[TcO(O 2 C 6 H 4 ) 2 ] ( 1 ) and Na[TcO(OCH 2 CH 2 O) 2 ] ( 2 ) have been prepared by reacting TcOCl 4 - with respective diols in methanol. Compound 2 was identified by its elemental analysis and field desorption mass spectrum. Crystals of compound 1 are monoclinic, C 2/ c , with cell dimensions a = 10.393(3), b = 13.835(3), c = 20.643(5) A, β = 101.74(3)° and four formula units in the unit cell. The crystal structure was determined by standard methods and refined to R 1 = 0.0694, R 2 = 0.0613, on the basis of 2887 independent reflections. The data were collected with use of Mo Kα radiation and a Syntex P 2 1 diffractometer. The anion of 1 is square pyramidal with a short TcO(oxo) bond (1.648(5) A). TcO distances to the diolate groups are longer (1.956(3), 1.958(3) A). The technetium atom lies 0.7014(4) A out of the plane of the four diolate oxygen atoms. Compound 2 is hydrolytically unstable in pure water, but can be stabilized by the addition of a several-fold molar excess of ethylene glycol. Compound 1 decomposes minimally in pure water after 24 h. These complexes are shown to be good structural models for 99m Tc-radiopharmaceuticals containing purely oxygen-donor ligands. Comparison of the physical properties of the structurally characterized members of the series of complexes with core structures TcOS x O (4- x ) ( x = O, 2, 4) shows a shift to low energy in the frequency of the terminal oxygen-technetium band in the IR correlated with increasing softness of the basal plane donor atom set.

2 citations


Cited by
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592 citations

Journal ArticleDOI
TL;DR: In this article, the main structural features of 240 Tc complexes whose X-ray crystal structure has been determined during the period 1986-1992 were reported, with 294 references and 41 figures.

140 citations