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Bryon E. Petersen
Researcher at University of Florida
Publications - 93
Citations - 10668
Bryon E. Petersen is an academic researcher from University of Florida. The author has contributed to research in topics: Stem cell & Liver regeneration. The author has an hindex of 37, co-authored 91 publications receiving 10381 citations. Previous affiliations of Bryon E. Petersen include Wake Forest Baptist Medical Center & Wake Forest Institute for Regenerative Medicine.
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Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TL;DR: A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.
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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Naohiro Terada,Takashi Hamazaki,Masahiro Oka,Masanori Hoki,Diana M. Mastalerz,Yuka Nakano,Edwin M. Meyer,Laurence Morel,Bryon E. Petersen,Edward W. Scott +9 more
TL;DR: It is demonstrated that mouse bone marrow cells can fuse spontaneously with embryonic stem cells in culture in vitro that contains interleukin-3, which, without detailed genetic analysis, might be interpreted as ‘dedifferentiation’ or transdifferentiation.
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In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
Li-Jun Yang,Shiwu Li,Heather M. Hatch,Kim Ahrens,Janet G. Cornelius,Bryon E. Petersen,Ammon B. Peck +6 more
TL;DR: Evidence is presented that highly purified adult rat hepatic oval “stem” cells, which are capable of differentiation to hepatocytes and bile duct epithelium, can trans-differentiate into pancreatic endocrine hormone-producing cells when cultured in a high-glucose environment.
Journal ArticleDOI
Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.
Gene D. Block,Joseph Locker,William C. Bowen,Bryon E. Petersen,Sikandar L. Katyal,Stephen C. Strom,Thomas Riley,Tamara A. Howard,George K. Michalopoulos +8 more
TL;DR: The hypothesis that mature hepatocytes can function as or be a source of bipotential facultative hepatic stem cells (hepatoblasts) is supported and evidence for the growth factor and matrix signals that govern these complex phenotypic transitions of facultative stem cells are provided.
Journal ArticleDOI
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat
TL;DR: It is reported herein that HOC express high levels of Thy‐1, a cell surface marker used in conjunction with CD34 and lineage‐specific markers to identify hematopoietic stem cells, and a highly enriched population was obtained.