Burak Aday

Bio: Burak Aday is an academic researcher. The author has contributed to research in topics: Dimedone & Catalysis. The author has an hindex of 8, co-authored 12 publications receiving 291 citations.

One-pot, efficient and green synthesis of acridinedione derivatives using highly monodisperse platinum nanoparticles supported with reduced graphene oxide

Abstract: An efficient, high yielding, quick method has been developed for the synthesis of acridinedione derivatives via a one-pot, multi-component condensation of dimedone (1), various aromatic aldehydes (2a–i), and various aromatic amines (3a,b) using highly monodisperse platinum nanoparticles supported with reduced graphene oxide (Pt NPs@rGO) as a recyclable heterogeneous catalyst. This method takes advantage of the fact that water/ethanol (a green solvent) is used in combination with Pt NPs@rGO nanoparticles as a catalyst which can be easily recovered and reused for further runs. This highly monodisperse catalyst has been used for the first time as a highly stable, exceptionally reusable, isolable, bottleable, long-lived and highly efficient catalyst for the synthesis of acridinedione derivatives from dimedone, aromatic aldehydes and various amines with great catalytic performance. The synthesized catalyst was characterized using transmission electron microscopy, high resolution electron microscopy, X-ray diffraction, Raman and X-ray photoelectron spectroscopy techniques. The results of these analyses show the formation of highly crystalline and colloidally stable highly monodisperse Pt NPs@rGO. This highly monodisperse catalyst is a most efficient catalyst which gives the high yield of products in a short time.

Pt NPs@GO as a highly efficient and reusable catalyst for one-pot synthesis of acridinedione derivatives

Abstract: Graphene oxide decorated with platinum nanoparticles (Pt NPs@GO) has been used for the first time as a highly stable, exceptionally reusable, isolable, bottleable, long-lived and highly efficient catalyst for the synthesis of acridinedione derivatives from dimedone, aromatic aldehydes and various amines with great catalytic performance. All the acridinedione compounds were synthesized in DMF in a single process through two successive reactions (aldol condensation and Michael addition) in the presence of highly efficient Pt NPs@GO. The synthesized catalyst was characterized by transmission electron microscopy (TEM), high resolution electron microscopy (HRTEM), X-ray diffraction (XRD), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). All products obtained using Pt NPs@GO were characterized by FT-IR, 1H-NMR, 13C-NMR and HRMS techniques.

Graphene Oxide as Highly Effective and Readily Recyclable Catalyst Using for the One-Pot Synthesis of 1,8-Dioxoacridine Derivatives.

Abstract: Graphene oxide as a highly stable, reusable, isolable, and efficient catalyst has been used for the first time for the synthesis of acridinedione derivatives from dimedone, aromatic aldehydes and various amines with great catalytic performance. One pot synthesis of acridinedione compounds were performed using highly efficient graphene oxide.

Functionalized Multi-Walled Carbon Nanotubes (f-MWCNT) as Highly Efficient and Reusable Heterogeneous Catalysts for the Synthesis of Acridinedione Derivatives

Abstract: Addressed herein, carboxylic acid groups were immobilized onto carbon nanotubes and their catalytic properties were examined for the first time for the synthesis of acridinedione derivatives, opening new paths in the investigation of catalysis and their comparison with carbon-based materials. An efficient methodology for the synthesis of acridinedione derivatives has been achieved by one-pot, multi-component condensation of dimedone, substitute aromatic aldehydes, various aromatic amines and, in the presence of the easily available, inexpensive, and nontoxic f-MWCNTs as versatile biodegradable catalysts. At this method, f-MWCNTs carrying simple carboxylic acid functionalities catalyze the model reaction in ethanol providing the product in a quantitative yield. This highly monodisperse catalyst is one of the most efficient catalysts which gives the highest yield of products in the shortest time. Its high-yield efficiency, clean, eco-friendly, simple work-up procedure, and easy purification are regarded to be the main advantages of this method. The synthesized compounds are characterized using spectroscopic (IR, 1H-NMR, 13C-NMR and HRMS) techniques.

Enhanced electrocatalytic activity and durability of Pt nanoparticles decorated on GO-PVP hybride material for methanol oxidation reaction

Abstract: The alternative energy request is force to find effective electro catalysts used in fuel cell implementations and to enhance the efficiency of existing materials. In this study, graphene oxide (GO) and polyvinylpyrrolidone (PVP) supported shape-controlled platinum nanoparticles (Pt NPs) were newly synthesized with one-pot approach and used as anode materials in the direct methanol fuel cells (DMFCs). The examination for the performance of Pt @GO-PVP NPs was carried out in methanol oxidation reactions (MOR). Pt @GO-PVP catalysts exhibit high stability and activity against the MOR. The methanol oxidation reactions current can reach to 43 mA and can maintain 82.9% of the initial value even after 1000 cycles. The GO-PVP support material provides higher surface area and absorbs more methanol molecules for more efficient oxidation.

Progress in the development of human carbonic anhydrase inhibitors and their pharmacological applications: Where are we today?

Abstract: Carbonic anhydrases (CAs, EC 4.2.1.1) are widely distributed metalloenzymes in both prokaryotes and eukaryotes. They efficiently catalyze the reversible hydration of carbon dioxide to bicarbonate and H+ ions and play a crucial role in regulating many physiological processes. CAs are well-studied drug target for various disorders such as glaucoma, epilepsy, sleep apnea, and high altitude sickness. In the past decades, a large category of diverse families of CA inhibitors (CAIs) have been developed and many of them showed effective inhibition toward specific isoforms, and effectiveness in pathological conditions in preclinical and clinical settings. The discovery of isoform-selective CAIs in the last decade led to diminished side effects associated with off-target isoforms inhibition. The many new classes of such compounds will be discussed in the review, together with strategies for their development. Pharmacological advances of the newly emerged CAIs in diseases not usually associated with CA inhibition (neuropathic pain, arthritis, cerebral ischemia, and cancer) will also be discussed.

Recent developments in the synthesis and biological activity of acridine/acridone analogues

Abstract: Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases. Therefore, many scientists seek new, more effective, more selective and less toxic drugs. Acridine/acridone derivatives constitute a class of compounds with a broad spectrum of biological activity and are of great interest to scientists. To date, many acridine/acridone analogues have been obtained, which, inter alia, exhibit antitumour (e.g., (1–5)), antimicrobial (e.g., (59)), and antiviral (e.g., (61)) activities and are applicable in the treatment of Alzheimer's disease (e.g., (26)). However, in many cases, their clinical application is limited and excluded because of side effects. In this survey, we describe acridine and acridone derivatives reported since 2013, methods of their synthesis and their potential clinical applications.