B
Burkhard Poeggeler
Researcher at University of Göttingen
Publications - 77
Citations - 8583
Burkhard Poeggeler is an academic researcher from University of Göttingen. The author has contributed to research in topics: Melatonin & Pineal gland. The author has an hindex of 40, co-authored 72 publications receiving 8108 citations. Previous affiliations of Burkhard Poeggeler include University of Valladolid & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Melatonin: Nature's most versatile biological signal?
Seithikurippu R. Pandi-Perumal,V. Srinivasan,Georges J.M. Maestroni,Daniel P. Cardinali,Burkhard Poeggeler,Rüdiger Hardeland +5 more
TL;DR: Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients.
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A review of the evidence supporting melatonin's role as an antioxidant
Russel J. Reiter,Daniela Melchiorri,Ewa Sewerynek,Burkhard Poeggeler,Lorneli Barlow-Walden,Jih Ing Chuang,Genaro G. Ortiz,Darío Acuña-Castroviejo +7 more
TL;DR: Melatonin is remarkably potent in protecting against free radical damage induced by a variety of means, and DNA damage resulting from either the exposure of animals to the chemical carcinogen safrole or to ionizing radiation is markedly reduced when melatonin is co‐administered.
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Melatonin stimulates brain glutathione peroxidase activity
Lornell Barlow-Walden,Russel J. Reiter,Mitsushi Abe,Marta I. Pablos,Armando Menendez-Pelaez,Li‐Dun ‐D Chen,Burkhard Poeggeler +6 more
TL;DR: Brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels, which might be an important mechanism by which melatonin exerts its potent neuroprotective effects.
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Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis
TL;DR: Experiments investigating the effects of endogenous excitatory amino acid antagonists and stimulants of melatonin biosynthesis such as magnesium may finally lead to novel therapeutic approaches for the prevention of degeneration and dysdifferentiation associated with diseases related to premature aging.
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The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
TL;DR: Melatonin represents the most potent physiological scavenger of hydroxyl radicals found to date, and recent findings suggest an essential role of this indoleamine for protection from hydroxy radical-induced carcinogenesis and neurodegeneration.