Author
C. Ainsworth
Bio: C. Ainsworth is an academic researcher. The author has contributed to research in topics: Ketene & Proton-coupled electron transfer. The author has an hindex of 5, co-authored 12 publications receiving 273 citations.
Papers
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TL;DR: In this article, it was shown that the freedom of rotation about a carbon carbon double bond is determined by the attached substituents, and the mechanism of this reaction has been established as intramolecular employing 18O.
193 citations
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TL;DR: Alkali-metal reduction of disubstituted malonates or treatment of esters with base in the presence of trimethylchlorosilane gives high yields of the reactive disubstrituted keten alkyl trimethylsilyl acetals, while diethyl oxalate, under similar conditions is reduced to 1,2diethyl-1,2-bis(trimethylsiloxy)ethylene as discussed by the authors.
Abstract: Alkali-metal reduction of disubstituted malonates or treatment of esters with base in the presence of trimethylchlorosilane gives high yields of the reactive disubstituted keten alkyl trimethylsilyl acetals, while diethyl oxalate, under similar conditions is reduced to 1,2-diethyl-1,2-bis(trimethylsilyloxy)ethylene.
25 citations
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8 citations
Cited by
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18 Mar 2005
TL;DR: This main section includes 250 two-page entries about Named Organic Reactions, which lists the Named Reactions by Synthetic Type and by their Utility.
Abstract: I. Foreword by E. J. Corey II Introduction by K. C. Nicolaou III. Preface IV. Explanation of the Use of Colors in the Schemes and Text V. List of Abbreviations VI. List of Named Organic Reactions (this main section includes 250 two-page entries) VII. Named Organic Reactions in Alphabetical Order VIII. Appendix: Listing of the Named Reactions by Synthetic Type and by their Utility IX. References X. Index
347 citations
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224 citations
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TL;DR: As synthetic targets, the C-nucleosides have deceptively simple structures, and the design of synthetic routes to them must take two important factors into account: the methods selected for C-C bond formation at the anomeric center should be stereocontrolled.
Abstract: Publisher Summary The C-nucleosides are a group of C-glycosylated heterocycles in which the anomeric carbon atom is attached to the heterocycle by a C-C bond. C-nucleosides have been mainly from fermentation sources, and have been found to exhibit a variety of interesting biological properties. Pyrazomycin has significant antiviral activity. Formycin, formycin B, and oxazinomycins exhibit, in addition, antitumor activity. The biological importance of most of the naturally occurring C-nucleosides has prompted the exploration of synthetic routes leading to these compounds and their analogs. As synthetic targets, the C-nucleosides have deceptively simple structures, and the design of synthetic routes to them must take two important factors into account. Firstly, the methods selected for C-C bond formation at the anomeric center should be stereocontrolled because the structures known thus far are, with two exceptions, β-D-glycosyl compounds. Secondly, the carbon atom attached to the glycosyl group in a C-nucleoside precursor should be appropriately substituted or be amenable to substitution, so as to allow the elaboration of the other heterocyclic portion of the molecule.
199 citations
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TL;DR: In this article, it was shown that the freedom of rotation about a carbon carbon double bond is determined by the attached substituents, and the mechanism of this reaction has been established as intramolecular employing 18O.
193 citations
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TL;DR: In this paper, strong base and chlorotrimethylsilane were used to convert α, β- β, γ-unsaturated esters to the corresponding mixed vinylketene acetals.
133 citations