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C. D. Marsden

Researcher at King's College

Publications -  6
Citations -  6111

C. D. Marsden is an academic researcher from King's College. The author has contributed to research in topics: Homovanillic acid & Dopamine. The author has an hindex of 5, co-authored 6 publications receiving 5774 citations.

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Corticocortical inhibition in human motor cortex.

TL;DR: In ten normal volunteers, a transcranial magnetic or electric stimulus that was subthreshold for evoking an EMG response in relaxed muscles was used to condition responses evoked by a later, suprathreshold magnetic orElectric test shock to suggest that the suppression was produced by an action on cortical, rather than spinal excitability.
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Simple and complex movements in a patient with infarction of the right supplementary motor area

TL;DR: A detailed physiological investigation from a patient with a right SMA lesion is presented and it is suggested that the defect of motor programming in Parkinson's disease is likely to reflect functional deafferentation of the SMA.
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Levels of Met-enkephalin, Leu-enkephalin, substance P and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment.

TL;DR: The neuropeptide alterations previously reported in Parkinson's disease are probably not secondary to the severe lesion of dopaminergic neurones, but constitute another intrinsic feature of the disease.
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The effect of carbidopa on plasma and muscle levels of L-dopa, dopamine, and their metabolites following L-dopa administration to rats.

TL;DR: Muscle appears to accumulate L‐dopa at a site where decarboxylation is not totally prevented by concurrent carbidopa administration, and where dopamine is not degraded as actively as in other tissues, which has implications for the therapeutic response to L-dopa in Parkinson's disease.