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C. Günther

Bio: C. Günther is an academic researcher from University of Würzburg. The author has an hindex of 1, co-authored 1 publications receiving 67 citations.


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Journal ArticleDOI
04 Aug 2006-Science
TL;DR: A safe and convenient cross-coupling strategy for the large-scale synthesis of biaryls, commercially important structures often found in biologically active molecules, using a copper catalyst to generate the carbon nucleophiles in situ via decarboxylation of easily accessible arylcarboxylic acid salts.
Abstract: We present a safe and convenient cross-coupling strategy for the large-scale synthesis of biaryls, commercially important structures often found in biologically active molecules. In contrast to traditional cross-couplings, which require the prior preparation of organometallic reagents, we use a copper catalyst to generate the carbon nucleophiles in situ, via decarboxylation of easily accessible arylcarboxylic acid salts. The scope and potential economic impact of the reaction are demonstrated by the synthesis of 26 biaryls, one of which is an intermediate in the large-scale production of the agricultural fungicide Boscalid.

801 citations

Journal ArticleDOI
TL;DR: In this article, a review of the state of the art in the field of the synthesis and the application of silica-supported Pd catalysts in carbon-carbon and carbon-nitrogen coupling reactions is presented.

472 citations

Journal ArticleDOI
TL;DR: A palladium-catalyzed enantioselective synthesis of indole-based atropisomers via an intramolecular dynamic kinetic C–H cyclization through the TADDOL-derived phosphoramidite ligand proves to be most efficient in this directing-group-free transformation.
Abstract: We report here a palladium-catalyzed enantioselective synthesis of indole-based atropisomers via an intramolecular dynamic kinetic C–H cyclization. The TADDOL-derived phosphoramidite ligand proves to be most efficient in this directing-group-free transformation, delivering products with up to 96:4 er. The thermal stability of the axial chirality of the atropisomers has also been investigated.

141 citations

Journal ArticleDOI
TL;DR: This review presents the experimental requirements for the hyphenation and the theoretical background of the calculation of UV and CD spectra, which is exemplified by some recent HPLC-CD applications to the elucidation of absolute configurations of most diverse compounds of mainly natural origin.

117 citations

Journal ArticleDOI
TL;DR: The principles and applicability of optical rotation, and electronic and vibrational circular dichroism aided by quantum chemical calculations are presented to determine absolute configuration and conformation through examples of stereochemical analysis of natural products with emphasis on the possibility of combined analysis and pitfalls for natural product chemists.

112 citations