Author
C. W. Schimelpfenig
Bio: C. W. Schimelpfenig is an academic researcher. The author has contributed to research in topics: Ring (chemistry) & Dieckmann condensation. The author has an hindex of 1, co-authored 1 publications receiving 21 citations.
Topics: Ring (chemistry), Dieckmann condensation
Papers
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22 citations
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206 citations
01 Jan 1983
129 citations
TL;DR: Suzuki coupling of 18 and 30 affords 9 as an interconverting mixture of two atropisomers as well as the macrocyclic ketone 8 in 57% yield.
31 citations
TL;DR: This personal account article will focus on α‐aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders’ and Shilvock's seminal review.
Abstract: Due to their numerous reactivity modes, α-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on α-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders' and Shilvock's seminal review. Natural α-aminonitriles will also briefly be treated.
23 citations
TL;DR: In this paper, die chemischen Eigenschaften der Dithia-cyclohexanone werden naher beschrieben, i.α.ω-Dicarbonsaureester, deren beide zu den Carboxylen β-standigen CH2-Gruppen durch S-Atome ersetzt sind.
22 citations