Author
Calvin B. Bridges
Other affiliations: California Institute of Technology, Carnegie Institution for Science, University of Wisconsin-Madison
Bio: Calvin B. Bridges is an academic researcher from Columbia University. The author has contributed to research in topics: Drosophila melanogaster & Drosophila (subgenus). The author has an hindex of 28, co-authored 57 publications receiving 4347 citations. Previous affiliations of Calvin B. Bridges include California Institute of Technology & Carnegie Institution for Science.
Papers published on a yearly basis
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629 citations
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03 Feb 2019TL;DR: Page 15, table 1, column 4, for "158" read "138".
Abstract: Page 15, table 1, column 4, for "158" read "138"
Page 16, line 7, for "1146" read "1246"
Page 30, table 16, heading, for "we" read "w"
Page 42, table 34 A , pedigree 1320, under heading wevf s, for "— —" read "47"
Page 43, table 34 C , pedigree 1348, under sf, for "49" read "39"
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TL;DR: Page 108, last line of text, for "P/P″" read "P′/ P″."
Abstract: Page 108, last line of text, for "P/P″" read "P′/P″."
Page 120, last line, for "δ v " read "δ y ."
Page 123, line 10, for "4Nn" read "4Nu."
Page 125, line 1, for "q" read "q."
Page 126, line 12, for "q" read "q."
Page 135, line 5 from bottom, for "y4Nsq" read "e4Nsq."
Page 141, lines 8
7,850 citations
TL;DR: The frequency of a given gene in a population may be modified by a number of conditions including recurrent mutation to and from it, migration, selection of various sorts and, far from least in importance, were chance variation.
4,833 citations
TL;DR: A first-generation CNV map of the human genome is constructed through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia, underscoring the importance of CNV in genetic diversity and evolution and the utility of this resource for genetic disease studies.
Abstract: Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have constructed a first-generation CNV map of the human genome through the study of 270 individuals from four populations with ancestry in Europe, Africa or Asia (the HapMap collection). DNA from these individuals was screened for CNV using two complementary technologies: single-nucleotide polymorphism (SNP) genotyping arrays, and clone-based comparative genomic hybridization. A total of 1,447 copy number variable regions (CNVRs), which can encompass overlapping or adjacent gains or losses, covering 360 megabases (12% of the genome) were identified in these populations. These CNVRs contained hundreds of genes, disease loci, functional elements and segmental duplications. Notably, the CNVRs encompassed more nucleotide content per genome than SNPs, underscoring the importance of CNV in genetic diversity and evolution. The data obtained delineate linkage disequilibrium patterns for many CNVs, and reveal marked variation in copy number among populations. We also demonstrate the utility of this resource for genetic disease studies.
4,275 citations
TL;DR: A rosy transposon (ry1), constructed by inserting a chromosomal DNA fragment containing the wild-type rosy gene into a P transposable element, transformed germ line cells in 20 to 50 percent of the injected rosy mutant embryos indicating that the visible genetic defect in the host strain could be fully and permanently corrected by the transferred gene.
Abstract: Exogenous DNA sequences were introduced into the Drosophila germ line. A rosy transposon (ry1), constructed by inserting a chromosomal DNA fragment containing the wild-type rosy gene into a P transposable element, transformed germ line cells in 20 to 50 percent of the injected rosy mutant embryos. Transformants contained one or two copies of chromosomally integrated, intact ry1 that were stably inherited in subsequent generations. These transformed flies had wild-type eye color indicating that the visible genetic defect in the host strain could be fully and permanently corrected by the transferred gene. To demonstrate the generality of this approach, a DNA segment that does not confer a recognizable phenotype on recipients was also transferred into germ line chromosomes.
3,004 citations
TL;DR: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms and used in medicine, science, and engineering.
Abstract: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.
2,699 citations