C
Cameron S. McAlpine
Researcher at Harvard University
Publications - 35
Citations - 1796
Cameron S. McAlpine is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 25 publications receiving 973 citations. Previous affiliations of Cameron S. McAlpine include McMaster University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Igor Theurl,Ingo Hilgendorf,Ingo Hilgendorf,Manfred Nairz,Piotr Tymoszuk,David Haschka,Malte Asshoff,Shun He,Louisa M.S. Gerhardt,Tobias A. W. Holderried,Markus Seifert,Sieghart Sopper,Ashley M. Fenn,Atsushi Anzai,Sara Rattik,Cameron S. McAlpine,Milan Theurl,Peter Wieghofer,Yoshiko Iwamoto,Georg F. Weber,Nina K. Harder,Benjamin G. Chousterman,Tara Arvedson,Mary McKee,Fudi Wang,Oliver M D Lutz,Emanuele Rezoagli,Jodie L. Babitt,Lorenzo Berra,Marco Prinz,Matthias Nahrendorf,Guenter Weiss,Ralph Weissleder,Herbert Y. Lin,Filip K. Swirski +34 more
TL;DR: The liver is identified as the primary organ that supports rapid erythrocyte removal and iron recycling, and a mechanism by which the body adapts to fluctuations in ery throatcyte integrity is uncovered.
Journal ArticleDOI
Sleep modulates haematopoiesis and protects against atherosclerosis.
Cameron S. McAlpine,M. Kiss,M. Kiss,M. Kiss,Sara Rattik,Shun He,Anne Vassalli,Colin Valet,Atsushi Anzai,Christopher T. Chan,John E. Mindur,Florian Kahles,Wolfram C. Poller,Vanessa Frodermann,Ashley M. Fenn,Annemijn F. Gregory,Lennard Halle,Yoshiko Iwamoto,Friedrich Felix Hoyer,Christoph J. Binder,Christoph J. Binder,Peter Libby,Mehdi Tafti,Thomas E. Scammell,Matthias Nahrendorf,Filip K. Swirski +25 more
TL;DR: The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability, and this results identify a neuro-immune axis that links sleep to haematopoiesis and Atherosclerosis.
Journal ArticleDOI
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Vanessa Frodermann,David Rohde,Gabriel Courties,Nicolas Severe,Maximilian J. Schloss,Hajera Amatullah,Cameron S. McAlpine,Sebastian Cremer,Friedrich Felix Hoyer,Fei Ji,Ian D. van Koeverden,Fanny Herisson,Lisa Honold,Gustavo Santos Masson,Shuang Zhang,Jana Grune,Yoshiko Iwamoto,Stephen P. Schmidt,Gregory R. Wojtkiewicz,I-Hsiu Lee,Karin Gustafsson,Gerard Pasterkamp,Saskia C. A. de Jager,Ruslan I. Sadreyev,Jean G. MacFadyen,Peter Libby,Paul M. Ridker,David T. Scadden,Kamila Naxerova,Kate L. Jeffrey,Filip K. Swirski,Matthias Nahrendorf +31 more
TL;DR: Together, data show that physical activity alters HSPCs via modulation of their niche, reducing hematopoietic output of inflammatory leukocytes, as well as cardiovascular inflammation and outcomes.
Journal ArticleDOI
The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.
Atsushi Anzai,Jennifer L. Choi,Shun He,Ashley M. Fenn,Manfred Nairz,Sara Rattik,Cameron S. McAlpine,John E. Mindur,Christopher T. Chan,Yoshiko Iwamoto,Benoit Tricot,Gregory R. Wojtkiewicz,Ralph Weissleder,Peter Libby,Matthias Nahrendorf,James R. Stone,Burkhard Becher,Filip K. Swirski +17 more
TL;DR: It is found that shortly and transiently after onset of ischemia, human and mouse cardiac fibroblasts produce granulocyte/macrophage colony-stimulating factor (GM-CSF) that acts locally and distally to generate and recruit inflammatory and proteolytic cells.
Journal ArticleDOI
Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Alexander Heyde,David Rohde,Cameron S. McAlpine,Shuang Zhang,Friedrich Felix Hoyer,Jeffrey M. Gerold,David Cheek,Yoshiko Iwamoto,Maximilian J. Schloss,Katrien Vandoorne,Oriol Iborra-Egea,Christian Muñoz-Guijosa,Antoni Bayes-Genis,Johannes G. Reiter,Morgan Craig,Filip K. Swirski,Matthias Nahrendorf,Martin A. Nowak,Kamila Naxerova +18 more
TL;DR: In this paper, the authors show that hematopoietic stem cell division rates are increased in mice and humans with atherosclerosis, and that increased stem cell proliferation expedites somatic evolution and expansion of clones with driver mutations.