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Carl J. March
Researcher at Amgen
Publications - 96
Citations - 19749
Carl J. March is an academic researcher from Amgen. The author has contributed to research in topics: Receptor & Peptide sequence. The author has an hindex of 44, co-authored 96 publications receiving 19351 citations. Previous affiliations of Carl J. March include University of North Carolina at Chapel Hill & Seattle University.
Papers
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Journal ArticleDOI
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
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Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
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An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Journal ArticleDOI
Molecular cloning of the interleukin-1 beta converting enzyme
Douglas P. Cerretti,Carl J. Kozlosky,Bruce Mosley,Nicole Nelson,Kirk P. Van Ness,Teresa A. Greenstreet,Carl J. March,Shirley R. Kronheim,Teresa Druck,Linda A. Cannizzaro,Kay Huebner,Roy A. Black +11 more
TL;DR: A complementary DNA encoding a protease that carries out this cleavage has been cloned in this paper, and the gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.
Journal ArticleDOI
A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification.
Thomas P. Hopp,K S Prickett,Virginia L. Price,Randell T. Libby,Carl J. March,Douglas P. Cerretti,David L. Urdal,Paul J. Conlon +7 more
TL;DR: A small hydrophilic peptide of eight amino acids was engineered onto the N-terminus of a variety of recombinant lymphokines for the purpose of aiding in their detection and purification from yeast supernatants or E. coli extracts.