Carlo M. Croce

TL;DR: The results suggest that periostin overexpression might be a potential marker for early cancer detection in a specific subset of hereditary breast carcinomas triggered by cancer-associated BRCA1 mutations that affect the BRCT tandem domain.

TL;DR: An expression profiling approach provides evidence that the CDK inhibitor p27Kip1 regulates miRs expression following cell cycle exit following contact inhibition, and proposes a new role for miR-223 in the regulation of breast cancer progression.

TL;DR: The most recent findings concerning the role of microRNAs in triggering or exacerbating muscle wasting in cancer cachexia are discussed, while mentioning about possible roles played by long non-coding RNAs and ADAR-mediated miRNA modifications.

TL;DR: HMGA2-driven leukemia in mice closely resembles spontaneous human T-ALL, indicating that HMGA2 transgenic mice should serve as an important model for investigating basic mechanisms and potential new therapies of relevance to human T -ALL.

TL;DR: In vitro analyses and in vivo tumorigenicity studies show that restoration of Fhit protein induces tumor suppression in 50% of tumor cell lines tested, and viral vector-mediated FHIT gene transfer to Fhit-deficient mice not only prevents but reverses the carcinogen-induced tumor development in vivo, in accordance with the oncosuppressive properties of F hit protein.