Carlo M. Croce

TL;DR: It is shown that tumor progression locus-2 (TPL2), a MAP3 kinase activated by T NFα, protects from TNFα-induced apoptosis by preventing the activation of caspase-8, and that the combination of TPL2 knockdown and TNF α treatment induces synthetic lethality.

TL;DR: Western blot images representing PATZ, BCL6, and tubulin in Fig. 6C did not accurately represent the experimental results and different lanes were erroneously duplicated.

TL;DR: MiREDiBase as discussed by the authors is a manually curated catalog of editing events in miRNAs, which includes 3,059 unique validated and putative editing sites from 626 pre-miRNAs in humans and three primates.

TL;DR: To address the role of miRNAs in the regulation and maintenance of the hematopoietic stem cell state and leukemogenesis, 6 primary AML patient samples were sorted into 4 populations based on the expression of CD34/CD38 and miRNA array analysis was performed, and BIC/miR-155 was found to be over-expressed in leukemic stem cells (LSC).

TL;DR: Because of interest in mechanisms of recombination involved in chromosomal deletions in neoplastic disease, and their relation to possible rearrangements in normal tissues, circular DNA molecules from human tissue are studied with a long‐term goal of investigating them as possible by‐products of physiologically relevant intrachromosomal recombination events.