C
Carlo M. Croce
Researcher at Ohio State University
Publications - 1156
Citations - 199822
Carlo M. Croce is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 198, co-authored 1135 publications receiving 189007 citations. Previous affiliations of Carlo M. Croce include University of Nebraska Medical Center & University of California, Los Angeles.
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Journal Article
Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.
TL;DR: It is suggested that BCL-2 blocks the glucocorticoid-induced apoptosis of the 380 pre-B-lymphocytes by extending their survival when the level of c-myc expression is repressed.
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MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer.
TL;DR: How the factors encoded by transcripts targeted by these five miRNAs, be they transcription factors, tumor‐suppressors, or regulators of different signaling pathways, can deregulate the immune response and favor pro‐tumor immunity is focused on.
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CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
Amaia Lujambio,Anna Portela,Julia Liz,Sonia Melo,Simone Rossi,Riccardo Spizzo,Carlo M. Croce,George A. Calin,Manel Esteller +8 more
TL;DR: The finding that, in addition to microRNAs, another class of ncRNAs (T-UCRs) undergoes DNA methylation-associated inactivation in transformed cells supports a model in which epigenetic and genetic alterations in coding and non-coding sequences cooperate in human tumorigenesis.
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PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells
Paolo Neviani,Jason G. Harb,Joshua J. Oaks,Ramasamy Santhanam,Christopher J. Walker,Justin Ellis,Gregory Ferenchak,Adrienne M. Dorrance,Carolyn Paisie,Anna M. Eiring,Yihui Ma,Hsiaoyin C. Mao,Bin Zhang,Mark Wunderlich,Philippa C. May,Chaode Sun,Sahar A. Saddoughi,Jacek Bielawski,William Blum,Rebecca B. Klisovic,Janelle A. Solt,John C. Byrd,Stefano Volinia,Jorge E. Cortes,Claudia S. Huettner,Steffen Koschmieder,Tessa L. Holyoake,Steven M. Devine,Michael A. Caligiuri,Carlo M. Croce,Ramiro Garzon,Besim Ogretmen,Ralph B. Arlinghaus,Ching-Shih Chen,Robert Bittman,Peter Hokland,Denis-Claude Roy,Dragana Milojkovic,Jane F. Apperley,John M. Goldman,Alistair Reid,James C. Mulloy,Ravi Bhatia,Guido Marcucci,Danilo Perrotti,Danilo Perrotti +45 more
TL;DR: It is shown that persistence of leukemic HSCs in BM requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A) and expression--but not activity--of the BCR-ABL1 oncogene, and Targeting the JAK2/ PP2A/β-catenin network in quiescent H SCs with PADs has the potential to treat TKI-refractory CML and relieve lifelong patient dependence on
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Karyotype-specific microRNA signature in chronic lymphocytic leukemia.
Rosa Visone,Laura Z. Rassenti,Angelo Veronese,Angelo Veronese,Cristian Taccioli,Stefan Costinean,Baltazar D. Aguda,Stefano Volinia,Manuela Ferracin,Jeff Palatini,Veronica Balatti,Hansjuerg Alder,Massimo Negrini,Thomas J. Kipps,Carlo M. Croce +14 more
TL;DR: The use of the microRNA-based classifications may yield clinically useful biomarkers of tumor behavior in CLL, and IGHV unmutated, high expression of ZAP-70 protein, and low expression of themiR-223, miR-29c, mi R-29b, and miR -181 family were strongly associated with disease progression in Cll cases harboring 17p deletion.