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Carlos A. Pardo
Researcher at Johns Hopkins University School of Medicine
Publications - 196
Citations - 18806
Carlos A. Pardo is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Transverse myelitis & Myelopathy. The author has an hindex of 56, co-authored 184 publications receiving 16523 citations. Previous affiliations of Carlos A. Pardo include Johns Hopkins University & University of Maryland, College Park.
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Journal ArticleDOI
Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate
Jeffrey D. Rothstein,Margaret Dykes-Hoberg,Carlos A. Pardo,Lynn A. Bristol,Lin Jin,Ralph W. Kuncl,Yoshikatsu Kanai,Matthias A. Hediger,Yanfeng Wang,Jerry P Schielke,Devin Franklin Welty +10 more
TL;DR: It is suggested that glial glutamate transporters provide the majority of functional glutamate transport and are essential for maintaining low extracellular glutamate and for preventing chronic glutamate neurotoxicity.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.
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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
Philip C. Wong,Carlos A. Pardo,David R. Borchelt,Michael K. Lee,Neal G. Copeland,Nancy A. Jenkins,Sangram S. Sisodia,Don W. Cleveland,Don W. Cleveland,Donald L. Price +9 more
TL;DR: Mutations in Cu/Zn superoxide dismutase cause a subset of cases of familial amyotrophic lateral sclerosis, and four lines of mice accumulating one of these mutant proteins (G37R) develop severe, progressive motor neuron disease.
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Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.
John T. Morgan,Gursharan Chana,Carlos A. Pardo,Cristian L. Achim,Katerina Semendeferi,Jody Buckwalter,Eric Courchesne,Ian P. Everall +7 more
TL;DR: The activation profile described represents a neuropathological alteration in a sizeable fraction of cases with autism, and microglial activation may play a central role in the pathogenesis of autism in a substantial proportion of patients.
Journal ArticleDOI
Guillain–Barré Syndrome Associated with Zika Virus Infection in Colombia
Beatriz Parra,Jairo Lizarazo,Jorge Andres Jimenez-Arango,Andrés Felipe Zea-Vera,Guillermo González-Manrique,José Vargas,Jorge A. Angarita,Gonzalo Zuniga,Reydmar Lopez-Gonzalez,Cindy L. Beltran,Karen H. Rizcala,Maria T. Morales,Oscar Pacheco,Martha L. Ospina,Anupama Kumar,David R. Cornblath,Laura S. Muñoz,Lyda Osorio,Paula Barreras,Carlos A. Pardo +19 more
TL;DR: The evidence of ZikV infection documented by RT-PCR among patients with the Guillain-Barré syndrome during the outbreak of ZIKV infection in Colombia lends support to the role of the infection in the development of the Guillian-B Barré syndrome.