Carlos Bustamante

TL;DR: It is found that a simple bottleneck model cannot explain the derived nucleotide polymorphism site frequency spectrum in rice, and a bottleneck model that incorporates selective sweeps, or a more complex demographic model that includes subdivision and gene flow are more plausible explanations for patterns of variation in domesticated rice varieties.

TL;DR: This work combines genome-wide polymorphism data from PCR-based exon resequencing, comparative genomic data across mammalian species, and protein structure predictions to estimate the number of functionally consequential single-nucleotide polymorphisms carried by each of 15 and 20 African American and 20 European American individuals.

TL;DR: Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.

TL;DR: Methods for manipulating single molecules are yielding new information about both the forces that hold biomolecules together and the mechanics of molecular motors.

TL;DR: The complete genome sequence of the Iceman is reported and 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from the genomic data is shown.