C
Carlos Bustamante
Researcher at Stanford University
Publications - 799
Citations - 122303
Carlos Bustamante is an academic researcher from Stanford University. The author has contributed to research in topics: Population & DNA. The author has an hindex of 161, co-authored 770 publications receiving 106053 citations. Previous affiliations of Carlos Bustamante include Lawrence Berkeley National Laboratory & University of California.
Papers
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Journal ArticleDOI
Genomic scans for selective sweeps using SNP data
Rasmus Nielsen,Scott Williamson,Yuseob Kim,Melissa J. Hubisz,Andrew G. Clark,Carlos Bustamante +5 more
TL;DR: This work shows that a new parametric test, based on composite likelihood, has a high power to detect selective sweeps and is surprisingly robust to assumptions regarding recombination rates and demography (i.e., has low Type I error).
Journal ArticleDOI
Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies
D. Collin,Felix Ritort,Christopher Jarzynski,Steven B. Smith,Ignacio Tinoco,Carlos Bustamante,Carlos Bustamante +6 more
TL;DR: It is shown that the Crooks fluctuation theorem can be used to determine folding free energies for folding and unfolding processes occurring in weak as well as strong nonequilibrium regimes, thereby providing a test of its validity under such conditions.
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A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
Rasmus Nielsen,Rasmus Nielsen,Carlos Bustamante,Andrew G. Clark,Stephen Glanowski,Timothy B. Sackton,Melissa J. Hubisz,Adi Fledel-Alon,David M. Tanenbaum,Daniel Civello,Thomas J. White,John J. Sninsky,Mark Raymond Adams,Michele Cargill +13 more
TL;DR: This work compares 13,731 annotated genes from humans to their chimpanzee orthologs to identify genes that show evidence of positive selection, and hypothesizes that positive selection in some of these genes may be driven by genomic conflict due to apoptosis during spermatogenesis.
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ClinGen — The Clinical Genome Resource
Heidi L. Rehm,Jonathan S. Berg,Lisa D. Brooks,Carlos Bustamante,James P. Evans,Melissa J. Landrum,David H. Ledbetter,Donna Maglott,Christa Lese Martin,Robert L. Nussbaum,Sharon E. Plon,Erin M. Ramos,Stephen T. Sherry,Michael S. Watson +13 more
TL;DR: A patient’s family pursues genetic testing that shows a “likely pathogenic” variant for the condition on the basis of a study in an original research publication, and a different variant is found that is determined to be pathogenic.
Journal ArticleDOI
Reversible unfolding of single RNA molecules by mechanical force.
TL;DR: The force-dependent equilibrium constants for folding/unfolding these single RNA molecules and the positions of their transition states along the reaction coordinate are determined.