Carlos Bustamante

TL;DR: Using optical tweezers, it is shown that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules can be induced into either native or misfolding pathways by modulating the relaxation rate of applied force.

TL;DR: A rapid and scalable route to synthetic mucin constructs with precisely defined glycan densities and chain lengths established via N-carboxyanhydride polymerization is developed, which are the first synthetic analogs to the authors' knowledge to feature the native α-GalNAc linkage to serine with molecular weights similar to native mucins, solving a nearly 50-year synthetic challenge.

TL;DR: It is demonstrated that S1 promotes RNA unwinding by binding to the single-stranded RNA formed transiently during the thermal breathing of the RNA base pairs and that S2 dissociation results in RNA rezipping, and that a multistep scheme greatly expedites S1 unwinding of an RNA structure compared to a single-step mode.

TL;DR: An overview of a research platform that provides essential germplasm, genotypic and phenotypic data and analytical tools for dissecting phenotype–genotype associations in rice is presented, to empower basic research discoveries in rice by linking sequence diversity with physiological, morphological, and agronomic variation.

TL;DR: Se sequencing data from over 1,000 individuals in twenty-one human populations, as well as ancient human genomes, are used to perform a fine-scale investigation of the evolutionary history of DARC and infer that, prior to the sweep of FY*O, all three alleles were segregating in Africa, as highly diverged populations from Asia and ≠Khomani San hunter-gatherers share the same FY*A haplotypes.