Carlos Cano

TL;DR: A peer production system for recording and organizing variant evaluations according to standard evidence guidelines is developed, creating a public forum for reaching consensus on interpretation of clinically relevant variants.

TL;DR: This study shows that the simultaneous integration of information about diseases, drugs and targets can lead to a significant improvement in drug repositioning tasks.

TL;DR: Although tissue gene microarray profiling has led to promising data in cancer, to date, none of the identified signatures or molecular markers in locally advanced rectal cancer has been successfully validated as a diagnostic or prognostic tool applicable to routine clinical practice.

TL;DR: ProphNet is a generic network-based prioritization tool that allows to integrate an arbitrary number of interrelated biological entities to accomplish any prioritization task, and works on top of any heterogeneous network.

TL;DR: This paper proposes a new method to obtain potentially-overlapping biclusters, the Possibilistic Spectral Biclustering algorithm (PSB), based on Fuzzy Technology and Spectral Clustering, and tests it on S. cerevisiae cell cycle expression data and on a human cancer dataset.