C
Carlos Lerin
Researcher at Johns Hopkins University School of Medicine
Publications - 1
Citations - 2841
Carlos Lerin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Carbohydrate metabolism & Glycolysis. The author has an hindex of 1, co-authored 1 publications receiving 2634 citations.
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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T. Rodgers,Carlos Lerin,Wilhelm Haas,Steven P. Gygi,Bruce M. Spiegelman,Pere Puigserver +5 more
TL;DR: It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan.