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Carlos R. Morales
Researcher at McGill University
Publications - 145
Citations - 8201
Carlos R. Morales is an academic researcher from McGill University. The author has contributed to research in topics: Sertoli cell & Prosaposin. The author has an hindex of 49, co-authored 136 publications receiving 7754 citations. Previous affiliations of Carlos R. Morales include Washington State University.
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Journal ArticleDOI
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Kiran Musunuru,Kiran Musunuru,Kiran Musunuru,Alanna Strong,Maria Frank-Kamenetsky,Noemi E. Lee,Tim Ahfeldt,Tim Ahfeldt,Katherine V. Sachs,Xiaoyu Li,Hui Li,Nicolas Kuperwasser,Vera M. Ruda,James P. Pirruccello,James P. Pirruccello,Brian Muchmore,Ludmila Prokunina-Olsson,Jennifer L. Hall,Jennifer L. Hall,Eric E. Schadt,Carlos R. Morales,Sissel Lund-Katz,Michael C. Phillips,Jamie Wong,William Cantley,Timothy Racie,Kenechi Ejebe,Kenechi Ejebe,Marju Orho-Melander,Olle Melander,Victor Koteliansky,Kevin Fitzgerald,Ronald M. Krauss,Chad A. Cowan,Chad A. Cowan,Sekar Kathiresan,Sekar Kathiresan,Daniel J. Rader +37 more
TL;DR: Functional evidence for a novel regulatory pathway for lipoprotein metabolism is provided and it is suggested that modulation of this pathway may alter risk for MI in humans.
Journal ArticleDOI
The Selectivity of the Human Placenta in the Transfer of Plasma Proteins from Mother to Fetus
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Dramatically Different Phenotypes in Mouse Models of Human Tay-Sachs and Sandhoff Diseases
Daniel Phaneuf,Nobuaki Wakamatsu,Jing-Qi Huang,Anita Borowski,Alan C. Peterson,Sheila R. Fortunato,Gerd Ritter,Suleiman A. Igdoura,Carlos R. Morales,Guylaine Benoit,Guylaine Benoit,Beverly R. Akerman,Daniel Leclerc,Nobuo Hanai,Jamey D. Marth,Jacquetta M. Trasler,Jacquetta M. Trasler,Roy A. Gravel +17 more
TL;DR: It is proposed that Hexa -/- mice escape disease through partial catabolism of accumulated GM2 via GA2 (asialo-GM2) through the combined action of sialidase and beta-hexosaminidase B.
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The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin
TL;DR: The results show that the trafficking of SAPs is dependent on sortilin, demonstrating a novel lysosomal trafficking.
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Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
Alanna Strong,Qiurong Ding,Andrew C. Edmondson,John S. Millar,Katherine V. Sachs,Xiaoyu Li,Arthi Kumaravel,Margaret Ye Wang,Ding Ai,Liang Guo,Eric T. Alexander,David Nguyen,Sissel Lund-Katz,Michael C. Phillips,Carlos R. Morales,Alan R. Tall,Sekar Kathiresan,Edward A. Fisher,Kiran Musunuru,Daniel J. Rader +19 more
TL;DR: Functional evidence is provided that genetically increased hepatic sortilin expression both reduces hepatic apolipoprotein B secretion and increases LDL catabolism, providing dual mechanisms for the very strong association between increased hepatics sortil in expression and reduced plasma LDL-C levels in humans.